Specific human CYP 450 isoform metabolism of a pentachlorobiphenyl (PCB-IUPAC# 101)

Biochemical and Biophysical Research Communications
Joseph E McGraw, Donald P Waller

Abstract

Polychlorinated biphenyl IUPAC# 101-PCB 101 (chlorination pattern-2,2',4',5,5') is a common, persistent non-coplanar PCB congener found in the ambient environment but information related to its metabolism in humans is lacking. Previous studies indicate PCB 101 is rapidly metabolized in mammals through CYP 2B and 3A family enzymes. Recently, PCB metabolism through a 2A family isoform in hamsters was also reported. To specifically identify the human CYP 450 isoforms responsible for PCB 101 metabolism, we compared human microsome metabolism to metabolism using several specific recombinant human CYP isoforms. These data characterized selective and extensive metabolism by human CYP 2A6. The product formed was the 4-hydroxy-PCB 101 metabolite (4-hydroxy-2,2',4',5,5') and was the only major metabolite observed in the recombinant and human microsome investigation. This is important information for predicting human specific toxicokinetics of PCBs.

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Citations

Jan 17, 2013·Environmental Science & Technology·Guangshu ZhaiJerald L Schnoor
Feb 1, 2012·Expert Opinion on Drug Metabolism & Toxicology·Joseph McGraw, Donald Waller
Jan 30, 2015·Critical Reviews in Toxicology·Fabian A GrimmLarry W Robertson
Dec 18, 2015·Environmental Science and Pollution Research International·Cunxian MaJerald L Schnoor
Jan 5, 2010·Environmental Toxicology and Pharmacology·Joseph E McGraw, Donald P Waller
May 22, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shintaro MiseHideyuki Inui
Oct 27, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tsutomu ShimadaMasayuki Komori
Apr 4, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elisa OllikainenTiina M Sikanen
Jul 4, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eric UwimanaHans-Joachim Lehmler
Sep 23, 2020·Toxics·Harmanpreet Kaur PanesarPamela J Lein
May 1, 2009·Journal of the American Chemical Society·Yasuhiro MieYasuo Komatsu
Dec 24, 2018·Environmental Science & Technology·Eric UwimanaHans-Joachim Lehmler
Jul 1, 2009·Archives of Biochemistry and Biophysics·Patrick SchäferRalph Menzel

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