Specific in vitro IgG subclass synthesis and lymphocyte proliferation responses in herpes virus encephalitis

Acta Neurologica Scandinavica
T MathiesenB Wahren

Abstract

Cerebrospinal fluid, peripheral blood lymphocytes (PBL) and sera from 5 patients with herpes simplex encephalitis (HSVE), 3 with varicellae zoster (VZV) meningoencephalitis and 5 with encephalitis of unknown origin (NUD) were analyzed. Lymphocytes from both blood and CSF were shown to synthesize anti-VZV IgG subclasses in VZV meningoencephalitis and anti-HSV IgG subclasses in HSVE. The subclass patterns of CSF and in vitro synthesized anti-viral IgG were similar, suggesting that a considerable portion of the antiviral IgG subclasses detected are synthesized in the CNS compartment. Antigen presentation in vitro seemed to produce a heterologous IgG4 and/or 3 response in 3 patients. Lymphocyte proliferation was detectable in response to HSV and VZV, respectively.

References

Jan 1, 1978·Acta Neurologica Scandinavica·A Frydén, H Link
Jan 1, 1976·The New England Journal of Medicine·A Rivenson, R E Madden
Dec 1, 1985·Journal of Virological Methods·P LjungmanV A Sundqvist
May 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·T MathiesenB Wahren
Jan 1, 1985·The Journal of Experimental Medicine·L MayerH G Kunkel
Sep 1, 1988·Journal of Neurology·T MathiesenB Wahren
Jul 1, 1984·Journal of Clinical Microbiology·V A SundqvistB Wahren
Jan 1, 1982·Immunological Reviews·Y J Rosenberg
Nov 1, 1982·Journal of Virological Methods·V A Sundqvist

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.