Specific in vitro interferon-gamma and IL-2 production as biomarkers during treatment of chronic Q fever

Frontiers in Microbiology
T SchoffelenM van Deuren

Abstract

Antibiotic treatment of chronic Q fever is cumbersome and of long duration. To monitor treatment, there is a need for alternative biomarkers. Coxiella burnetii-specific interferon (IFN)-γ and interleukin (IL)-2 production reflect the type of effector and memory T-cell response. In chronic Q fever, C. burnetii-specific IFN-γ production is higher and IL-2 production is lower than in individuals with past Q fever. Here we explore whether C. burnetii-specific IFN-γ and IL-2 production correlate to treatment response. We studied the longitudinal C. burnetii-specific IFN-γ/IL-2 ratio in fifteen proven chronic Q fever patients. All patients were followed for at least 18 months during antibiotic treatment. Treatment was considered successful when clinical recovery was observed, a positive PCR for C. burnetii DNA in blood became persistently negative, anti-phase I IgG showed a fourfold decrease or more, and imaging techniques showed disappearance of infectious foci. Overall, the IFN-γ/IL-2 ratio declined when patients experienced a successful treatment outcome. When treatment failed, IFN-γ/IL-2 ratios did not significantly decrease. The median (±IQR) slope of the longitudinal IFN-γ/IL-2 ratio with successful treatment was -2.10 (-7.02 t...Continue Reading

References

Oct 9, 1999·Clinical Microbiology Reviews·M Maurin, D Raoult
Jul 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F FenollarD Raoult
Apr 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Rekha SeshadriJohn F Heidelberg
Dec 17, 2003·The Journal of Experimental Medicine·Souheil-Antoine YounesRafick-Pierre Sekaly
Nov 30, 2004·The Lancet Infectious Diseases·Madhukar PaiJohn M Colford
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre HarariGiuseppe Pantaleo
Mar 29, 2005·The Lancet Infectious Diseases·D RaoultJl Mege
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nasser SemmoPaul Klenerman
Mar 1, 2006·Lancet·Neil R ParkerAlan Morton Bell
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerry A MillingtonAjit Lalvani
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cécile LandaisDidier Raoult
Jul 17, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Botelho-NeversD Raoult
Apr 19, 2008·The Journal of Infectious Diseases·Ajit Lalvani, Kerry A Millington
Jun 25, 2009·BMC Infectious Diseases·Valeria SargentiniRoberto Nisini
Nov 6, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R BiselliR Nisini
Jul 20, 2010·The Lancet Infectious Diseases·Matthieu MillionDidier Raoult
Mar 12, 2011·Emerging Infectious Diseases·Diane FrankelDidier Raoult
Jun 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wim van der HoekPeter M Schneeberger
Oct 29, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Vicky MerhejDidier Raoult
Jan 10, 2012·The Journal of Infection·M C A Wegdam-BlansUNKNOWN Dutch Q fever Consensus Group
Apr 4, 2012·Emerging Infectious Diseases·Linda M KampschreurJan Jelrik Oosterheert
May 26, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marjolijn C A Wegdam-BlansJoep A Teijink
Oct 9, 2012·Diagnostic Microbiology and Infectious Disease·Tineke HerremansHenk Bijlmer
Mar 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Teske SchoffelenMarcel van Deuren
Sep 6, 2013·BMC Infectious Diseases·Dennis G BartenChantal P Bleeker-Rovers
Oct 1, 2013·Expert Review of Anti-infective Therapy·Gilbert J Kersh
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T SchoffelenM van Deuren
Aug 30, 2014·Respiration; International Review of Thoracic Diseases·Paulin N EssoneChristoph Lange

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Citations

Jan 29, 2016·The Journal of Infection·Stephan P KeijmelMarcel van Deuren
Nov 26, 2016·Innate Immunity·James M BattistiMichael F Minnick
Jun 15, 2016·Infection and Immunity·Talita D FernandesDario S Zamboni
Nov 20, 2016·Clinical Microbiology Reviews·Carole EldinDidier Raoult
Apr 5, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Sheila B BuijsJan Jelrik Oosterheert
Jun 1, 2021·Journal of Medical Imaging and Radiation Oncology·Pirathaban SivabalanRobert Norton

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Methods Mentioned

BETA
PCR
imaging techniques
enzyme-linked immunosorbent assay
flow cytometry

Software Mentioned

Graphpad Prism

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