PMID: 933724Jun 1, 1976

Specific inhibition of hepatic fatty acid synthesis exerted by dietary linoleate and linolenate in essential fatty acid adequate rats

S D ClarkeG A Leveille


Dietary linoleate and linolenate were investigated for their ability to specifically inhibit liver and adipose tissue lipogenesis in meal-fed (access to food 900-1,200 hr), essential fatty acid (EFA) adequate rats. Supplementing a high carbohydrate diet containing 2.5% safflower oil with 3% palmitate 16:0, oleate 18:1, or linoleate 18:2 did not affect in vivo liver or adipose tissue fatty acid synthesis. However, 18:2 addition to the basal diet did result in a significant (P less than 0.05) decline of liver fatty acid synthetase (FAS) and glucose-6-phosphate dehydrogenase (G6PD) activities. When the safflower oil content of the basal diet was reduced to 1%, the addition of 3% 18:2 or linolenate 18:3 significantly (P less than 0.05) depressed hepatic FAS, G6PD, and in vivo fatty acid synthesis by 50%. Addition of 18:1 caused no depression in hepatic FAS activity but did result in a significant (P less than 0.05) decline in liver G6PD activity and fatty acid synthesis which was intermediate between basal and basal +18:2- or +18:3-fed animals. Adipose tissue rates of lipogenesis were completely unaffected by dietary fatty acid supplementation. Similarly, the addition of 3 or 5% 18:3 to a basal diet for only one meal resulted in no...Continue Reading


Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·R A WatermanG A Leveille
Nov 1, 1971·Comparative Biochemistry and Physiology. A, Comparative Physiology·D R RomsosG L Alee
Dec 17, 1969·Biochimica Et Biophysica Acta·L C ChuM A Williams
Jan 6, 1970·Biochemical and Biophysical Research Communications·Y Muto, D M Gibson
Mar 1, 1967·Canadian Journal of Physiology and Pharmacology·G A Leveille


May 1, 1980·Lipids·N IritaniY Kitamura
Feb 25, 2005·Lipids·Manabu T NakamuraTakayuki Y Nara
Jun 23, 1980·Biochimica Et Biophysica Acta·N IritaniM Morita
Jan 1, 1993·Progress in Lipid Research·S D Clarke, D B Jump
Oct 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T A HôI R Rowland
Sep 1, 1996·Progress in Lipid Research·D B JumpM Badin
May 1, 1980·The British Journal of Nutrition·G R Herzberg, N Janmohamed
Jan 1, 1997·Annual Review of Nutrition·H C TowleH M Shih
May 26, 2001·Annual Review of Nutrition·Lisa M Salati, B Amir-Ahmady
Jun 11, 2004·Annual Review of Nutrition·Manabu T Nakamura, Takayuki Y Nara
Jan 8, 2008·Bioscience, Biotechnology, and Biochemistry·Alessandra FerramoscaVincenzo Zara
Jan 1, 1978·FEBS Letters·R Jeffcoat, A T James
Jun 14, 2005·Biochimica Et Biophysica Acta·Lise MadsenKarsten Kristiansen
Jun 1, 1989·Japanese Journal of Cancer Research : Gann·K ImaidaY Hayashi

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