PMID: 3758280Oct 1, 1986Paper

Specific inhibition of myelination by lead in vitro; comparison with arsenic, thallium, and mercury

Experimental Neurology
A J Windebank

Abstract

Lead induces peripheral nerve segmental demyelination in rats. Arsenic and thallium produce a peripheral neuropathy characterized by axonal degeneration in humans. Mercury and thallium appear to damage both the peripheral and the central nervous system. It is not known whether this difference in effect is due to different molecular forms of the elements, to differential access to various compartments of the nervous system, or to intrinsically different properties of the elements. Using an in vitro model system of dorsal root ganglion neurons and morphometry of neurite outgrowth and myelination, we demonstrated that mercury and arsenic produce 50% inhibition of neurite outgrowth at 3.9 and 9.6 X 10(-6) M, respectively, whereas the same degree of inhibition is produced by 1.3 X 10(-4) M thallium and 3.3 X 10(-4) M lead. Lead also produces complete inhibition of myelination at 1 X 10(-6) M, suggesting that a primary effect on myelination is present in this model system as well as in the intact rodent.

References

Aug 1, 1985·Annals of Neurology·A J Windebank, P J Dyck
Nov 1, 1980·Journal of Neuropathology and Experimental Neurology·A J WindebankP J Dyck

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Citations

Dec 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·G AudesirkJ Przekwas
Oct 1, 1989·Brain Research. Developmental Brain Research·A J Windebank, M D Blexrud
Jan 1, 1996·Free Radical Biology & Medicine·F J Romero
Jun 7, 2005·Neurotoxicology·Jewel L Podratz, Anthony J Windebank
Sep 10, 2003·Toxicology Letters·V M RodríguezM Giordano
Dec 1, 1990·Australian and New Zealand Journal of Medicine·S D RogerD C Harris
Jan 6, 1999·Acta Neurologica Scandinavica·C C ChuT N Wu
Dec 14, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Dabrowska-BoutaU Rafałowska
Jul 17, 2010·Annals of the New York Academy of Sciences·Su-Feng FanAnya Maan-Yuh Lin
Aug 22, 2008·Journal of Pineal Research·Anya M Y LinC H Yang
Jan 30, 2008·Free Radical Biology & Medicine·Y H ChouA M Y Lin
May 1, 2016·Physiology & Behavior·Ehsan NassireslamiMohammad Sharifzadeh
Dec 14, 2007·Annals of the New York Academy of Sciences·P L ChaoAnya M Y Lin
Aug 12, 2005·Journal of Occupational and Environmental Medicine·Danella M HafemanJoseph H Graziano
Feb 23, 2021·Neurotoxicology and Teratology·John Paul WrightCatherine Sacarellos
Jul 1, 1989·Annals of Neurology·A J Windebank, M D Blexrud

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