PMID: 6412452Jul 30, 1983Paper

Specific inhibition of vaccinia virus growth by 2'-O-methyladenosine: isolation of a drug-resistant virus mutant

Virology
P Raczynski, R C Condit

Abstract

2'-O-methyladenosine (Am) specifically inhibits growth of vaccinia virus on cultured monkey kidney (BSC40) cells. Specificity has been demonstrated by the isolation of an Am-resistant mutant of vaccinia which forms plaques on Am-treated monolayers of BSC40 cells under conditions where wild type (wt) plaque formation is inhibited. Am inhibits virus growth at an early stage of infection; host shut off and early virus protein synthesis are inhibited by the drug.

Citations

Sep 1, 1987·Virology·J SetoE G Niles
Sep 27, 2003·Journal of Virology·Chelsea M ByrdDennis E Hruby
Oct 28, 2004·Journal of Virology·Chelsea M ByrdDennis E Hruby

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