PMID: 13698149Dec 1, 1960Paper

Specific inhibition of wheal-and-erythema responses with univalent haptens and univalent antibody fragments

The Journal of Experimental Medicine
F S FARAHH N EISEN

Abstract

Wheal-and-erythema responses were studied in normal human volunteers and in a single human subject who is sensitive to the 2,4-dinitrophenyl group. In the normal subjects, reactive skin sites were established by intradermal injection of purified rabbit antibody specific for the 2,4-dinitrophenyl group. In both the active and passively sensitized subjects, wheal-and-erythema was elicited by intradermal injection of a 2,4-dinitrophenyl protein, but not by injection of the same conjugate mixed with certain low molecular weight 2,4-dinitrophenyl haptens or with univalent fragments split by papain from anti-2,4-dinitrophenyl antibody. The latter fragments, unlike intact, bivalent, antibody, do not sensitize normal human skin sites. From these and other observations it is concluded that the wheal-and-erythema response in human skin requires mutually multivalent antigen and antibody. This requirement suggests that multimolecular complexes, containing at least 2 antigen and 2 antibody molecules, are essential in the pathogenesis of this allergic response.

References

Sep 1, 1955·The Journal of Clinical Investigation·M A ROTHSCHILDS A BERSON
Dec 1, 1960·The Journal of Experimental Medicine·F S FARAHH N EISEN

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Citations

Jul 1, 1969·Immunochemistry·N A Attallah, A H Sehon
Aug 1, 1973·The Journal of Allergy and Clinical Immunology·J K Kammermeyer, K P Mathews
Mar 6, 1975·The New England Journal of Medicine·C W Parker
Apr 1, 1962·The Journal of Experimental Medicine·C W PARKERH N EISEN
Jan 1, 1962·Vox Sanguinis·S BARANDUNH ISLIKER
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Dec 1, 1960·The Journal of Experimental Medicine·F S FARAHH N EISEN
Aug 1, 1985·Journal of the American Academy of Dermatology·B U Wintroub, R Stern
Nov 1, 1991·The Journal of Allergy and Clinical Immunology·R S Gruchalla, T J Sullivan
Nov 1, 1971·The Journal of Allergy and Clinical Immunology·F S Farah, Z Shbaklu
Jan 1, 1993·Annales Françaises D'anesthèsie Et De Rèanimation·A L de Weck
Mar 12, 1965·Annals of the New York Academy of Sciences·C W PARKER
Jun 1, 1963·The American Journal of Medicine·C W PARKER

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