Specific inhibitory synapses shift the balance from feedforward to feedback inhibition of hippocampal CA1 pyramidal cells

The European Journal of Neuroscience
David ElfantMarco Capogna

Abstract

Feedforward and feedback inhibition are two fundamental modes of operation widespread in the nervous system. We have functionally identified synaptic connections between rat CA1 hippocampal interneurons of the stratum oriens (SO) and interneurons of the stratum lacunosum moleculare (SLM), which can act as feedback and feedforward interneurons, respectively. The unitary inhibitory postsynaptic currents (uIPSCs) detected with K-gluconate-based patch solution at -50 mV had an amplitude of 20.0 +/- 2.0 pA, rise time 2.2 +/- 0.2 ms, decay time 25 +/- 2.2 ms, jitter 1.4 +/- 0.2 ms (average +/- SEM, n = 39), and were abolished by the gamma-aminobutyric acid (GABA)(A) receptor antagonist 2-(3-carboxypropyl)-3-amino-6-methoxyphenyl-pyridazinium bromide (SR 95531). Post hoc anatomical characterization revealed that all but one of the identified presynaptic neurons were oriens-lacunosum moleculare (O-LM) cells, whereas the postsynaptic neurons were highly heterogeneous, including neurogliaform (n = 4), basket (n = 4), Schaffer collateral-associated (n = 10) and perforant path-associated (n = 9) cells. We investigated the short-term plasticity expressed at these synapses, and found that stimulation at 10-40 Hz resulted in short-term depres...Continue Reading

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Citations

Oct 9, 2012·Nature Neuroscience·Richardson N LeãoKlas Kullander
Feb 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maria PangalosDietmar Schmitz
Dec 17, 2008·Journal of Neurophysiology·Ewa D ZarnowskaRobert A Pearce
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zechun PengCarolyn R Houser
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giulia Quattrocolo, Gianmaria Maccaferri
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sang-Hun LeeIvan Soltesz
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Jul 14, 2010·Cellular and Molecular Life Sciences : CMLS·Lucas MattThomas Kleppisch
Mar 16, 2013·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Angelo CompareAndrew Steptoe
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Dec 8, 2010·The Journal of Physiology·Gianmaria Maccaferri
Jun 11, 2020·Hippocampus·András EckerSrikanth Ramaswamy
May 20, 2021·Trends in Neurosciences·Klas Kullander, Lisa Topolnik
Jun 22, 2021·Frontiers in Neural Circuits·Eve HonoréJean-Claude Lacaille

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