PMID: 8964974Jan 1, 1996Paper

Specific innervation of the rat thalamus by grafted noradrenergic locus coeruleus neurons

Journal für Hirnforschung
Y Murata, Sadahiko Masuko

Abstract

Growth and distribution of noradrenaline (NA) fibres from the implant into the thalamus of host rats were examined at 5-13 months after the implantation by immunohistochemistry using NA or tyrosine hydroxylase antisera. Cell suspension dissociated from the locus coeruleus (LC) region of 14-day-old rat fetuses was implanted into the center of the unilateral thalamus in adult rats from which the noradrenergic afferents to the thalamus had been eliminated with 6-hydroxydopamine treatment. A dense network of varicose NA-immunoreactive (NA-IR) fibres extended laterally into the posterior thalamic nuclear group and the ventral posterolateral thalamic nucleus from the implant in a pattern similar to that the intrinsic noradrenergic fibres form in the normal thalamus, i.e. laterally rich and medially poor NA fibres. Electron microscopic observations revealed that varicosities of NA-IR fibres formed symmetrical as well as asymmetrical axodendritic synapses and axo-axonic synapses with the host neurons as seen in the normal thalamus. labelled dendrite-like fibres of graft origin penetrated deep into the host brain and received afferents from non-labelled axon terminals. Varicosities of NA-IR fibres in the LC implanted animal formed axo-d...Continue Reading

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