PMID: 9418042Jan 7, 1998Paper

Specific interactions between the K domains of AG and AGLs, members of the MADS domain family of DNA binding proteins

The Plant Journal : for Cell and Molecular Biology
H Y FanH Ma

Abstract

MADS domain (for MCM1, AG, DEFA and SRF) proteins are regulatory proteins found in all major eukaryotic kingdoms. Plant MADS domain regulatory proteins have a region of moderate sequence similarity that has been designated as the K domain, and its predicted coiled-coil structure suggests a role in establishing a protein-protein interaction. In vivo studies with the Arabidopsis AGAMOUS (AG) protein have indicated that the K domain is important for AG function. Using a bait fusion protein containing the K domain and the C-terminal region of AG in a yeast two-hybrid selection, 156 clones that encode potential AG-interacting proteins were identified. These clones each encode one of four highly related MADS domain proteins: AGL2, AGL4, AGL6 and AGL9. Additional analysis showed that the K domain of AG alone was able to bind the K domains of these AGLs. This binding was further confirmed by immunoprecipitation experiments using in vitro synthesized AG and AGL K domains. These results strongly suggest that AG interacts with AGL2, AGL4, AGL6 and AGL9 in vivo. Based on these results and previous observations, it is proposed that the AG function requires interaction with at least one of these AGL proteins, and such interactions contribute...Continue Reading

Citations

Jun 11, 2011·Plant Cell Reports·Huolin LuoChangbing Huang
Aug 5, 2005·Molecular Genetics and Genomics : MGG·Kerstin KaufmannGünter Theissen
Aug 23, 2007·Plant Molecular Biology·Inna LermontovaIngo Schubert
Nov 15, 2003·Molecular Phylogenetics and Evolution·Annette Becker, Günter Theissen
Nov 15, 2000·Trends in Plant Science·M E Gutierrez-Cortines, B Davies
Jul 4, 2001·Trends in Plant Science·T Jack
Feb 13, 2001·Current Opinion in Plant Biology·G Theissen
Dec 15, 2010·Genetics Research·Qiong ZhaoJohn Doebley
Jun 28, 2005·Nature·Antje BerkenAlfred Wittinghofer
Sep 10, 2005·Nature Reviews. Genetics·Beth A Krizek, Jennifer C Fletcher
Aug 29, 2003·The Plant Journal : for Cell and Molecular Biology·Yingzhen YangThomas Jack
Oct 9, 2002·The Plant Journal : for Cell and Molecular Biology·Meenu KapoorHiroshi Takatsuji
Aug 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kelsey D GalimbaVerónica S Di Stilio
Sep 15, 2011·Journal of Experimental Botany·Hitoshi Yoshida, Yasuo Nagato
May 29, 2002·Molecular Biology and Evolution·Katrin HenschelGünter Theissen
Mar 17, 2004·The Plant Cell·Thomas Jack
Jun 29, 2000·Annual Review of Biochemistry·C FerrándizM F Yanofsky
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Moriyah Zik, Vivian F Irish

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