PMID: 40136Jul 20, 1979

Specific labelling of postsynaptic alpha 1 adrenoceptors in rat heart ventricle by 3H-WB 4101

Naunyn-Schmiedeberg's Archives of Pharmacology
R RaismanS Z Langer

Abstract

The alpha-adrenoceptor ligand, 3H-WB 4101 binds to a single population of independent sites in the rat heart ventricle. These sites are not affected by chemical sympathectomy with 6-hydroxydopamine and thus appear to be located postsynaptically. The relative order of potencies for displacement of 3H-WB 4101 binding:prazosin greater than phentolamine greater than yohimbine, is characteristic of that of the alpha 1 type of adrenoceptors. In heart ventricle 3H WB-4101 thus seems to label specifically postsynaptically located alpha 1-adrenoceptors. The significance of the specificity of this ligand is discussed with relevance to its use in the central nervous system.

References

May 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·P J MiachP Meyer
Nov 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·H W WetzelS Z Langer
May 1, 1985·Pharmacology, Biochemistry, and Behavior·R R Ruffolo
Feb 15, 1988·Experientia·S Z Langer, A M Galzin
Nov 1, 1982·The British Journal of Dermatology·S Z Langer, C Pimoule
Jan 1, 1980·British Journal of Pharmacology·G KunosS O'Regan
Jan 1, 1997·Clinical and Experimental Hypertension : CHE·M MannelliF Franchi
Feb 12, 1996·FEBS Letters·H C LeeJ J Cai
Oct 1, 1982·The Journal of Pharmacy and Pharmacology·C MelchiorreL Brasili

Citations

Dec 1, 1978·European Journal of Pharmacology·M Butler, D H Jenkinson
Dec 1, 1975·European Journal of Pharmacology·K StarkeT Endo
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R W AlexanderR J Lefkowitz

Related Concepts

Dioxins
Myocardium
Entire Central Nervous System
WB 4101
Adrenergic alpha-Antagonists
Hydroxydopamine
Adrenergic Receptor
Oxidopamine
Binding (Molecular Function)
Prazosin

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