Specific laboratory methodologies achieve higher model for endstage liver disease (MELD) scores for patients listed for liver transplantation

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
J F TrotterCharles Phillips

Abstract

Priority for liver transplantation is currently based on the Model for Endstage Liver Disease (MELD) score, a mathematical function which includes the following objective variables: bilirubin, creatinine (Cr), and international normalized ratio (INR). We have noted that specific laboratory methodologies may yield consistently higher values of bilirubin, Cr, and INR. Therefore, we performed a study to determine if higher MELD scores could be obtained by utilizing laboratory methodologies selected to return higher laboratory values than standard methodologies used in our hospital's clinical laboratory. Phlebotomy was performed for routine clinical indications in 29 consecutive patients listed for liver transplantation. MELD scores were calculated using bilirubin, Cr, and INR from laboratory methods in our hospital's clinical laboratory (designated Lab #1) and from 2 other clinical laboratories (designated Lab #2 and Lab #3). The mean MELD score in our hospital's clinical laboratory (Lab #1) (13.6) was not significantly different than in Lab #2 (14.7), but in Lab #3, it was significantly higher by 20% (17.1), P <.03. Virtually all of the difference in MELD score between our hospital's clinical laboratory (Lab #1) and Lab #3 could ...Continue Reading

References

Feb 1, 1994·American Journal of Clinical Pathology·J Hammer
Dec 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Robert, O Chazouillères
May 21, 1999·Thrombosis Research·K W DensonJ Ruiz
May 9, 2001·American Journal of Veterinary Research·C IazbikG Kociba
Jul 19, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·B WoodhamsY Gourmelin
Jan 4, 2003·Gastroenterology·Russell WiesnerUNKNOWN United Network for Organ Sharing Liver Disease Severity Score Committee

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Citations

Aug 29, 2006·Wiener medizinische Wochenschrift·Ivo Graziadei
Sep 1, 2006·Digestive Diseases and Sciences·Vinay SundaramStephen H Caldwell
Sep 18, 2010·Journal of Thrombosis and Thrombolysis·Armando Tripodi
May 28, 2011·Internal and Emergency Medicine·Francesco MarongiuArmando Tripodi
Mar 15, 2005·Journal of Hepatology·Evangelos CholongitasAndrew K Burroughs
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Russell H Wiesner
Nov 4, 2010·Nature Reviews. Gastroenterology & Hepatology·Evangelos CholongitasAndrew K Burroughs
Sep 5, 2008·The New England Journal of Medicine·W Ray KimTerry M Therneau
Nov 7, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carol GouldingAndrew K Burroughs
Nov 9, 2007·Journal of Thrombosis and Haemostasis : JTH·A TripodiP M Mannucci
Sep 11, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Elias XirouchakisAndrew Kenneth Burroughs
Jul 14, 2005·Clinical Medicine & Research·John M Coombes, James F Trotter
Jun 13, 2009·World Journal of Gastroenterology : WJG·Eduardo Vilar GomezMaria del Rosario Abreu Vazquez
Jul 16, 2014·Clinics in Liver Disease·Russell H Wiesner
Jan 25, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·G E JungA Rahmel
Dec 16, 2009·Clinical Transplantation·A MehrabiB M Schmied
Sep 16, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H FernandezM Levy
Mar 20, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Patrick G Northup, Stephen H Caldwell
Jul 6, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Stephen Caldwell, Patrick G Northup
Mar 27, 2010·Biologicals : Journal of the International Association of Biological Standardization·A M H P van den BesselaarA Tripodi
Aug 27, 2009·Gastroenterology·Armando TripodiPier Mannuccio Mannucci
Jul 28, 2009·Gastroenterología y hepatología·Jordi ColmeneroMiguel Navasa
Dec 13, 2006·Clinics in Liver Disease·James F Trotter
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elizabeth C VernaRobert S Brown
Aug 8, 2009·British Journal of Haematology·Armando TripodiPier M Mannucci
Sep 20, 2007·Alimentary Pharmacology & Therapeutics·E CholongitasA K Burroughs
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·A TripodiA J Sanyal
May 22, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J F TrotterJ Kenison
May 15, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Ian Rowe, James Neuberger
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·T LismanS H Caldwell
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·A Tripodi
May 17, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Ton LismanRobert J Porte
Aug 5, 2006·Alimentary Pharmacology & Therapeutics·E CholongitasA K Burroughs
Jan 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E CholongitasA K Burroughs
Apr 26, 2006·Journal of Thrombosis and Haemostasis : JTH·J C Reverter

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