Specific lymphocyte blastogenic responses in children with cytomegalovirus and herpes simplex virus infections acquired early in infancy.

Infection and Immunity
R F PassC A Alford


Cell-mediated immune responses in 27 infants and children with cytomegalovirus (CMV) infection acquired between birth and 1 year of age were compared with responses in 13 children who had neonatal herpes simplex virus (HSV) infection. Infection was asymptomatic in 25 of 27 CMV-infected children; the 13 patients with HSV infection were all ill as newborns. The median age when studied was 46 months for children infected with CMV and 24 months for those infected with HSV. We measured lymphocyte transformation responses (LTRs) to CMV antigens in the former group and to HSV type 1 (HSV-1) (and in six cases to HSV-2) in the latter group, with the results expressed as a stimulation index. Based on the results in seropositive and seronegative adult control subjects, stimulation indexes of greater than or equal to 3 were considered indicative of a positive LTR. Among the CMV-infected children, a positive LTR was observed in 0 to 13 assays performed before 1 year of age, 3 of 8 assays performed between 1 and 4 years of age, and 9 of 15 assays performed over 4 years of age. In contrast, a positive LTR to HSV-1 was seen in 15 to 18 assays performed in children under 1 year of age and in 14 of 16 assays performed in survivors of neonatal HS...Continue Reading


Dec 1, 1979·The Journal of Infectious Diseases·M J LevinM S Hirsch
Jan 1, 1975·Infection and Immunity·S E StarrA J Nahmias
May 1, 1978·The Journal of Infectious Diseases·R B PollardT C Merigan
Nov 2, 1978·The New England Journal of Medicine·L CoreyK K Holmes
Oct 1, 1979·The Journal of Infectious Diseases·S E StarrS A Plotkin

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Dec 1, 1989·Developmental Medicine and Child Neurology·M A GentileR F Pass
Nov 14, 1985·The New England Journal of Medicine·S Stagno, R J Whitley
Sep 1, 1986·European Journal of Pediatrics·A HaywardL Corey
Nov 25, 2003·Pediatric Research·Mohamed Abdelhaye Elbou OuldGhislaine Sterkers
Feb 26, 2015·Journal of Clinical Immunology·Laura GibsonKatherine Luzuriaga
Sep 1, 1987·Journal of Medical Virology·R CaudaR F Pass
Aug 26, 2003·Journal of Medical Virology·Naomi HayashiKiyotaka Kuzushima
Apr 23, 2013·Clinical & Developmental Immunology·Soren Gantt, William J Muller
Jan 1, 1989·Pediatric Pathology·E Larson
Feb 13, 2002·The Pediatric Infectious Disease Journal·Douglas K MitchellStuart P Adler

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