Sep 1, 1977

Specific metabolic effects imposed by Streptococcus pneumoniae upon the response to femoral fracture in the rat

The American Journal of Clinical Nutrition
M V KaminskiL Strobel

Abstract

The possible potentiation of an infection upon the metabolic consequences of trauma was tested in rats using a 2 X 2 block design which included control, femoral fracture, pneumococcal infection, and fracture plus infection groups. Infection introduced unique metabolic effects different from those of starvation, femoral fracture, or both together. Infection-induced effects included an accelerated conversion of 14C-alanine to glucose, higher serum haptoglobin, alpha2-macrofetoprotein, copper, and ceruloplasmin values, and lower serum iron, zinc, and transferrin concentrations. The first three of these infection-induced effects were diminished in rats with a femoral fracture. No measured effect of infection was increased in traumatized rats.

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Mentioned in this Paper

Metabolic Process, Cellular
Gluconeogenesis
Serum Haptoglobin Measurement
Transferrin
Serum Proteins
Ceruloplasmin
Tf
TF gene
CP gene
Transferrin Measurement

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