Specific metabolic fingerprint of a dietary exposure to a very low dose of endosulfan

Journal of Toxicology
C CanletL Gamet-Payrastre

Abstract

Like other persistent organochlorine pesticides, endosulfan residues have been detected in foods including fruit, vegetables, and fish. The aim of our study was to assess the impact of a dietary exposure to low doses of endosulfan from foetal development until adult age on metabolic homeostasis in mice and to identify biomarkers of exposure using an (1)H-NMR-based metabonomic approach in various tissues and biofluids. We report in both genders an increase in plasma glucose as well as changes in levels of factors involved in the regulation of liver oxidative stress, confirming the prooxidant activities of this compound. Some metabolic changes were distinct in males and females. For example in plasma, a decrease in lipid LDL and choline content was only observed in female. Lactate levels in males were significantly increased. In conclusion, our results show that metabolic changes in liver could be linked to the onset of pathologies like diabetes and insulin resistance. Moreover from our results it appears that the NMR-based metabonomic approach could be useful for the characterization in plasma of a dietary exposure to low dose of pesticide in human.

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Citations

Aug 6, 2016·Journal of Immunotoxicology·Martha Cecilia Téllez-BañuelosGalina P Zaitseva
Nov 1, 2016·Bulletin of Environmental Contamination and Toxicology·Alessandro BrinatiMariella Bontempo Freitas
Nov 14, 2018·Lipids·Basma Damiri, William S Baldwin
May 4, 2020·Environmental Science and Pollution Research International·ShiTian SunLian-Shuang Zhang
May 22, 2020·Molecular and Cellular Endocrinology·M M MilesiJ Varayoud

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Methods Mentioned

BETA
NMR

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