PMID: 25730975Mar 4, 2015Paper

Specific molecular and morphological changes in cardiomyocytes of hibernating ground squirrels in different periods of annual cycle

Biofizika
E V KaradulevaN M Zakharova

Abstract

Structural and molecular changes in cardiomyocytes of hibernating ground squirrels in different periods of the annual cycle were analyzed by means of electron microscopy and polymerase chain reaction. Morphological analysis showed an increase in relative area of sarcoplasmic reticulum in cardiac muscle of ground squirrels preparing to torpor compared to active summer animals. The size of sarcoplasmic reticulum in cardiomyocytes of torpid animals was reliably less than in any other condition of ground squirrels in the annual cycle. The results of molecular analysis showed the decrease in sarcoplasmic reticulum Ca(2+)-ATPase gene (SERCA2a) expression .at all stages of hibernation process and also in periods of autumn activity compared to control mRNA level in active summer animals. The revealed season changes in structure of sarcoplasmic reticulum and sarcoplasmic reticulum Ca(2+)-ATPase gene expression are discussed in regard to adaptation of ground squirrels to hibernation.

References

Aug 1, 1983·Cryobiology·G D DukerB W Johansson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 17, 2002·Journal of Applied Physiology·Frank Van Breukelen, Sandra L Martin
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin
Feb 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Atsuko YataniDorothy E Vatner
Aug 4, 2005·Physiological Genomics·Katharine M BrauchMatthew T Andrews
Jul 25, 2006·International Journal of Cardiology·António AscensãoJosé Magalhães
Oct 11, 2007·Physiological Genomics·Jun YanThomas G Marr

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