PMID: 6169412Oct 1, 1981Paper

Specific neuritic pathways and arborizations formed by fetal mouse dorsal root ganglion cells within organized spinal cord explants in culture: a peroxidase-labeling study

Brain Research
N R SmalheiserS M Crain

Abstract

Extracellular microiontophoretic injections of horseradish peroxidase (HRP) into NGF-enhanced fetal mouse dorsal root ganglia (DRGs) produced an anterograde solid Golgi-like labeling of DRG neurites and their terminal arborizations within co-cultured spinal cord explants. In cultures of spinal cord transverse cross-sections with attached DRGs, the large NGF-enhanced DRGs remained in close proximity to the cord, often adjacent to both dorsal and ventral cord regions. Despite this, nearly all DRG neurites that entered the cord did so via dorsal root fascicles. They branched and ramified extensively within the dorsal region, taking on a wavy or kinky course and showed various types of arborizations. The density of cord innervation was much lower when isolated DRGs and cord explants were co-cultured 0.5-1 mm apart. Although fewer entering DRG fibers were labeled by our HRP injections the same qualitative growth and arborization patterns were seen within dorsal and ventral cord regions as in explants of cord with attached DRGs. When the facing edge contained both dorsal and ventral tissues, HRP-labeled DRG fibers entered dorsal regions selectively. DRG fibers readily entered, ramified and arborized within isolated strips of dorsal c...Continue Reading

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Citations

Jul 1, 1984·Developmental Biology·M J Katz
May 28, 2014·Journal of Neuroscience Methods·Gunja K PathakSameer B Shah
Jan 1, 1987·Annals of the New York Academy of Sciences·S M Crain
Sep 1, 1987·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·M A CornerA M M C Habets
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R E Baker, D G Janzen
Feb 19, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T M Jessell, J Dodd
Feb 1, 1987·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·M A CornerR E Baker
Jan 1, 1990·Neuroscience·N R Smalheiser

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