Specific Neuropilins Expression in Alveolar Macrophages among Tissue-Specific Macrophages

PloS One
Naing Ye AungMitsunori Yamakawa

Abstract

In the immune system, neuropilins (NRPs), including NRP-1 and NRP-2, are expressed in thymocytes, dendritic cells, regulatory T cells and macrophages. Their functions on immune cells around the neoplastic cells vary into pro-angiogenesis, tumor progression and anti-angiogenesis according to their ligands. Even though NRPs expression on malignant tumors and immune system has studied, a PubMed-based literature query did not yield any articles describing NRPs expression on tissue-specific macrophages. The aims of this study were (i) to detect NRPs expression on tissue-specific macrophages in the brain, liver, spleen, lymph node and lung; (ii) to observe NRPs expression in classes of macrophages, including alveolar macrophages (AMs), bronchial macrophages (BMs), interstitial macrophages (IMs), intravascular macrophages (IVMs) and macrophage subsets (M1, M2 and Mox) in lung; and (iii) to detect the co-expression of NRPs and dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) in AMs. Both NRPs were specifically detected in AMs among tissue-specific macrophages by immunohistochemistry (IHC). NRPs mRNA expression levels were characterized in normal lung by reverse transcriptase polymerase chain reaction (RT-PCR) and in situ-p...Continue Reading

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Citations

Aug 15, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xiaona AnJianbo Wu
Dec 13, 2019·Modern Rheumatology·Suran YangMitsunori Yamakawa
Apr 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert M ImmorminoTimothy P Moran
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Jul 3, 2021·Viruses·Yu-Jin KimJuan C de la Torre
Nov 5, 2020·Cell Reports·Léa SimoniMichael C Carroll

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Methods Mentioned

BETA
PCR
electrophoresis
bronchoalveolar lavage

Software Mentioned

SPSS ( Statistical Package for the Social Sciences )

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