Specific non-peroxide antibacterial effect of manuka honey on the Staphylococcus aureus proteome

International Journal of Antimicrobial Agents
Joanne M PackerElizabeth J Harry

Abstract

Manuka honey, derived from the New Zealand flowering plant Leptospermum scoparium, shows promise as a topical antibacterial agent and effective chronic wound dressing. The aim of this study was to determine the non-peroxide antibacterial effects of this honey on the proteome of the common wound pathogen Staphylococcus aureus. Proteomic analysis was performed on cells treated for a short time with manuka honey compared with the proteome of untreated cells as well as cells treated with a Leptospermum honey sample without antibacterial activity. Treatment with manuka honey resulted in a significant decrease in the bacterial cell growth rate as well as downregulation of ten and upregulation of two proteins. Nine of these proteins were also differentially expressed by cells treated with the inactive Leptospermum honey, but to a lesser degree, and the rate of bacterial growth was not affected. The differentially expressed proteins have roles in ribosomal function, protein synthesis, metabolic processes and transcription. Manuka honey uniquely caused downregulation of two proteins [dihydrolipoamide dehydrogenase (DLD) and elongation factor Tu (EF-Tu)] associated with two of these pathways as well as upregulation of one stress-related ...Continue Reading

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Citations

Jan 1, 2014·International Journal of Bacteriology·Michelle E M Campeau, Robin Patel
May 6, 2016·Frontiers in Microbiology·Dee A CarterElizabeth J Harry
Nov 19, 2014·The Journal of Antimicrobial Chemotherapy·Aled E L RobertsRose A Cooper
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May 17, 2017·Foot & Ankle Specialist·Alexander L LazaridesMichael S Kerzner
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Mar 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patricia Combarros-FuertesM Eugenia Tornadijo
Jun 21, 2013·American Journal of Therapeutics·Zafar H Israili
Aug 22, 2020·Biomaterials Science·Thomas J HallSophie C Cox
Sep 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irina NegutAlexandru Mihai Grumezescu
Nov 8, 2020·Antibiotics·Patricia Combarros-FuertesLeticia M Estevinho
Apr 7, 2021·The Journal of Pharmacy and Pharmacology·Joel B JohnsonMani Naiker
Apr 9, 2021·Journal of Pharmacy & Bioallied Sciences·Fatima Ibrahim JibrilSani Aliyu
Apr 15, 2021·Advances in Skin & Wound Care·Daniel R FelbaumLaura K Tom
May 21, 2021·Biomaterials Science·Zejun XuJun Wu
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena RatajczakJan Matysiak
Aug 19, 2021·Macromolecular Bioscience·Fengze MiaoQuangang Zhu

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