Specific overexpression of IL-7 in the intestinal mucosa: the role in intestinal intraepithelial lymphocyte development.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Hua YangDaniel H Teitelbaum

Abstract

IL-7 plays a crucial role in controlling T cell development and homeostasis. Since IL-7 may be derived from extraintestinal sources, and exogenous IL-7 broadly affects lymphoid populations, the actions of epithelial cell (EC)-derived IL-7 are not fully understood. The effect of intestinal specific expression of IL-7 on intestinal mucosal lymphocytes was investigated by using an IL-7 transgenic mouse model. We generated an intestinal EC-specific overexpressing IL-7 transgenic mouse model (IL-7(vill)) and compared their phenotype and function to wild-type C57BL/6J mice. EC-derived IL-7 overexpression was found to be exclusively in the small and large intestine. Numbers and subtypes of mucosal lymphocytes, including intraepithelial lymphocytes (IEL) and lamina propria lymphocytes (LPL), significantly changed in IL-7(vill) mice. From a functional standpoint, IEL proliferation also significantly increased in IL-7(vill) mice. IEL cytokine expression significantly changed in both T cell receptor (TCR)-alphabeta(+) and TCR-gammadelta(+) IEL subpopulations, including a significant increase in IFN-gamma and TNF-alpha as well as an increase in keratinocyte growth factor expression. EC expression of CD103 (integrin alpha(E)beta(7)), the li...Continue Reading

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Citations

Sep 14, 2013·Seminars in Immunopathology·Jörg Stange, Marc Veldhoen
May 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cherie T NgMichael B A Oldstone
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Jul 12, 2013·PloS One·Luc Van KaerDanyvid Olivares-Villagómez
Oct 23, 2008·Genesis : the Journal of Genetics and Development·Sabrina RothRon Smits
May 23, 2015·Digestive Diseases and Sciences·Atsuhito Nakao
Sep 28, 2013·Seminars in Cancer Biology·Zhanju LiuYingzi Cong
May 1, 2020·Clinical and Translational Gastroenterology·Susrutha Puthanmadhom NarayananAdil E Bharucha

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