Specific plasticity responses to unilaterally decreased or increased hearing intensity in the adult cochlear nucleus and beyond

Hearing Research
Robert-Benjamin Illing, Adrian Reisch

Abstract

Variations of sensory activation in strength and pattern are known to affect structure and function of the mammalian brain. Whereas such malleability is readily granted to forebrain structures at early developmental stages, acceptance of experience-dependent structural plasticity has been slow for the adult brainstem. Over the past years we have identified consequences of cochlear ablation, noise trauma, or electrical intracochlear stimulation on neurons and circuitry of the auditory brainstem of the adult rat. We found that loss of sensory activation as well as a substitution for it entail specific molecular, ultrastructural, and morphological changes to central auditory neurons. Here, we make a first attempt to compare these different patterns of central remodeling. We tentatively suggest that after hearing loss or intracochlear stimulation responses of the central neural network in the adult brainstem suit the concept of functional adaptation.

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Citations

Jul 31, 2009·The Journal of the Acoustical Society of America·Kevin J Munro, Jennifer Blount
Jan 29, 2008·Neuroscience·M E RubioD K Ryugo
Jul 17, 2007·Neuroreport·Kevin J MunroSuzanne C Purdy
Mar 10, 2010·Pediatrics·Joshua Kuang-Chao ChenLieber Po-Hung Li

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