Specific production of eosinophil colony stimulating factor from sensitized T cells from a patient with allergic eosinophilia

British Journal of Haematology
H EnokiharaH Shishido

Abstract

To explore the possibility that an eosinophil colony stimulating factor (EO-CSF) is elaborated independently of neutrophil CSF (N-CSF), we compared the effect on the production of EO-CSF and N-CSF of adding a specific antigen, an aspergillus extract, to peripheral blood leucocytes of an eosinophilic patient with allergic bronchopulmonary aspergillosis. Conditioned media prepared from the patient's mononuclear (MN) and T cells were assayed for EO-CSF and N-CSF activities by agar culture technique, using normal human nonphagocytic MN bone marrow cells as target cells. The addition of the specific antigen to the cultures of the patient's MN or T cells significantly stimulated the production of EO-CSF, but not that of N-CSF, while the patient's non-T cells and normal MN or T cells were not stimulated by the antigen challenge to produce either CSF. These results suggest that EO-CSF is a factor distinct from N-CSF, that its production is dependent on the presence of sensitized T cells with antigen-specific stimulation, and that it might be one of the causes of blood eosinophilia in this patient.

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Citations

Aug 1, 1990·British Journal of Haematology·H EnokiharaK Takatsu
Oct 1, 1995·Journal of Gastroenterology·S TerasakiM Kanai
Nov 1, 1988·International Journal of Cell Cloning·J L LiesveldJ K Brennan
Jul 3, 2002·Clinics in Chest Medicine·Devang M Savani, O P Sharma
Feb 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TerasakiM Unoura
Aug 1, 1992·American Journal of Hematology·T TakahashiH Imura

Related Concepts

Antigens, Fungal
Aspergillosis, Allergic Bronchopulmonary
Aspergillus
Protein Inducer MGI
Eosinophilia, Tropical
Eosinophil
Neutrophil Band Cells
T-Lymphocyte

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.