Specific projections of retina transplanted to rat brain

Experimental Brain Research
S C McLoon, R D Lund

Abstract

Retinae were taken from fetal rats and transplanted adjacent to the superior colliculus of neonatal rats. After 1 month survival, the transplants were surgically removed from the hosts, locally damaged or injected with horseradish peroxidase (HRP) to determine the distribution of the transplant efferents in the host brains. Histological examination of the transplants revealed cell and plexiform layers characteristic of normal retinae. Since the retinae were undifferentiated at the time of transplantation, this layering developed within the host. The only obvious differences from normal retina were that the layers were organized in rosettes or folded sheets and lacked well developed photoreceptor outer segments. In animals which had lesions or HRP injections confined to the retinal transplant, proper staining of sections of the host brain revealed transplant projections. These projections were confined to the optic tract and nuclei which are normally retinorecipient such as the superior colliculus and dorsal lateral geniculate nucleus. Projections were found along the border of non-retinorecipient nuclei such as the lateral posterior nucleus, but did not appear to enter these nuclei. It was observed that within the superior coll...Continue Reading

Citations

Apr 29, 1996·Brain Research·F HooverM H Hankin
Jan 1, 1984·Brain Research·S C McLoon, R D Lund
Jan 1, 1986·Brain Research·C B Jaeger
Jun 21, 1991·Brain Research. Developmental Brain Research·J D RadelR D Lund
Jun 1, 1987·Neuroscience·M del CerroC del Cerro
Jan 1, 1989·Neuroscience·V H Perry, R D Lund
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H Klassen, R D Lund
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P J CoffeyJ N Rawlins
Jan 1, 1992·The European Journal of Neuroscience·J. D. RadelR. D. Lund
Dec 1, 1988·Journal of Neurosurgery·R J TamargoH Brem
Jul 16, 1990·Brain Research·L S JenW Z Shen
Oct 1, 1988·Experimental Neurology·H Klassen, R D Lund
Jan 1, 1985·Annals of the New York Academy of Sciences·A Björklund, F H Gage
Jun 5, 2008·Cell Stem Cell·Deepak LambaThomas Reh

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