Specific protection of the binding sites of D-Ala2-D-Leu5-enkephalin (delta-receptors) and dihydromorphine (mu-receptors)

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
L E Robson, H W Kosterlitz

Abstract

Phenoxybenzamine causes a long-lasting inactivation of the opiate receptors of the mu- and delta-type in homogenates of guinea-pig brain. The effect is selectively prevented when, before exposure to phenoxybenzamine, the homogenate is pre-incubated with ligands of high affinity for either of the two binding sites, i.e. dihydromorphine for the mu-receptor and Tyr-D-Ala-Gly-Phe-D-Leu for the delta-receptor. In contrast, Tyr-D-Ala-Gly-Phe-L-Leu amide, which has high affinities for both binding sites, protects both receptor sites.

References

Jan 1, 1977·Psychoneuroendocrinology·L Terenius
Aug 15, 1974·Biochemical Pharmacology·T J CiceroE R Meyer
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C B Pert, S H Snyder

Citations

Jul 1, 1991·Medicinal Research Reviews·E J Simon
Jan 1, 1986·Annals of the New York Academy of Sciences·E J Simon
Jan 1, 1982·Annals of the New York Academy of Sciences·E J Simon
Jun 1, 1982·Journal of Neurochemistry·M Dornay, R Simantov
Oct 13, 2005·The Journal of Peptide Research : Official Journal of the American Peptide Society·F-D T LungJ-H Liu
Feb 1, 1985·Acta Pharmacologica Et Toxicologica·A Neil
Apr 1, 1985·International Journal of Peptide and Protein Research·M WestphalC H Li
Nov 1, 1980·British Journal of Pharmacology·M G GillanS J Paterson
Nov 16, 2012·Molecular Pharmacology·Charles Chavkin
May 1, 1985·Circulation Research·C J Homcy, R M Graham
Nov 1, 1982·Neurochemical Research·R B Rothman, T C Westfall
Jul 22, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·H W Kosterlitz
Jul 1, 1980·Journal of Neurochemistry·S H Snyder, R R Goodman
Jan 1, 1983·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R Bhanot, M Wilkinson
Jan 1, 1981·Medicinal Research Reviews·E T Iwamoto, W R Martin
Aug 1, 1981·British Journal of Pharmacology·H W KosterlitzL E Robson

Related Concepts

Metazoa
Brain
Dihydromorphine
Endorphins
Enkephalins
Cavia porcellus
Ligands
Morphine Derivatives Including Cocaine
Opioid Receptor
Structure-Activity Relationship

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