PMID: 6980415Jun 1, 1982Paper

Specific recognition of the product of a transferred major histocompatibility complex gene by cytotoxic T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America
J G WoodwardJ A Frelinger

Abstract

Mouse L cells transfected with a genomic clone containing the H-2Ld gene (8-5 cells) were shown to function as targets for H-2Ld-specific cytotoxic T lymphocytes (CTL). The CTL-mediated lysis of 8-5 cells was shown to be H-2Ld specific by the use of (i) CTL with restricted reactivity, (ii) unlabeled target inhibiton, and (iii) monoclonal antibody inhibiton. We also demonstrated that 8-5 cells could function as targets for antibody-plus-complement-mediated cell lysis. Specificity was confirmed by using H-2Ld-specific monoclonal antibodies. These experiments demonstrate that the gene products of a major histocompatibility complex genomic clone can be functionally expressed in a foreign cell and can mediate immunologically specific cellular interactions.

References

Oct 1, 1973·Journal of Immunological Methods·A B Peck, F H Bach
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C S DavidJ A Frelinger
Aug 1, 1974·European Journal of Immunology·G M Shearer
Aug 13, 1981·Nature·C WeyandJ Goronzy
Jan 1, 1980·Immunogenetics·R B Levy, T H Hansen

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Citations

Jan 1, 1984·Immunogenetics·E McLaughlin-TaylorJ A Frelinger
Dec 1, 1987·Veterinary Immunology and Immunopathology·P A Lalor, L A Herzenberg
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B S SchepartJ A Frelinger
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R MurrayJ A Frelinger
Aug 1, 1985·The Journal of Cell Biology·L A SungS Chien
Aug 1, 1985·The Journal of Cell Biology·L A SungS Chien
Jul 1, 1985·Immunological Reviews·J A Lopez de CastroJ L Strominger
Jan 1, 1984·CRC Critical Reviews in Biochemistry·R Kucherlapati, A I Skoultchi
Jan 1, 1984·Immunogenetics·M J MacchiJ A Frelinger

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