PMID: 6982789Sep 1, 1982Paper

Specific serum IgE antibodies to bacterial antigens in allergic lung disease

Clinical Allergy
R D Tee, J Pepys

Abstract

A radio-allergosorbent test (RAST) to measure specific IgE antibodies in man to whole bacterial cells of Streptococcus pneumoniae, Staphylococcus aureus and Haemophilus influenzae was developed to investigate different well-defined lung diseases (chronic bronchitis, allergic bronchopulmonary aspergillosis (ABPA), bronchial asthma allergic rhinitis, cystic fibrosis) and also in urticaria as compared with non-atopic blood donors. In addition, total IgE values and skin prick tests were assessed in these patients. The ABPA group gave the highest specific IgE RAST scores to all three bacteria, whilst the chronic bronchitis and cystic fibrosis groups also gave raised RAST scores with H. influenzae. There was a positive correlation between the patients' Sta. aureus and Str. pneumoniae immediate-type skin reactions and their RAST scores and total serum IgE concentrations, but there was only a low incidence of immediate-type skin test positivity to H. influenzae.

References

Apr 12, 1979·The New England Journal of Medicine·K SchopferS D Douglas
Oct 1, 1972·Immunochemistry·M Ceska, U Lundkvist
Dec 1, 1980·Allergy·R PauwelsM van der Straeten

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Citations

Sep 6, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael S BenningerHoward Levine
Jul 7, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K MatsuiA Nishikawa
Sep 6, 2006·Respiratory Research·Garrett J O'BrienGrzegorz Skibinski
Jul 16, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Diana C OtczykAllan W Cripps
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May 15, 2013·Asia Pacific Allergy·Woo-Jung SongYoon-Seok Chang
Jan 1, 1991·Pediatric Pulmonology·M KorppiK Launiala

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