Specific TCR gene rearrangements in mycosis fungoides: does advanced clinical stage show a preference?

Journal of Clinical Pathology
Etan MarksD Yitzchak Goldstein

Abstract

The relationship between the presence of specific T-cell receptor (TCR) gene rearrangements and clinical stage in mycosis fungoides (MF) has not been studied. We analysed a cohort of patients with a diagnosis of MF to determine the different types of specific TCR gene rearrangements present and their relationship to disease stage. A retrospective chart review was used to select patients with a diagnosis of MF who had a skin biopsy and a positive TCR gene rearrangement study in either blood or tissue and at least 2 years of clinical follow-up. 43 patients were identified and divided into two groups. The first group consisted of 23 patients with early stage disease (IA-IIA) that was either stable or went into partial or complete remission with minimal intervention. None of these patients advanced to late stage disease. The second group consisted of 20 patients who had either late stage disease at diagnosis or progressed to late stage disease at some point in time. In the first group, only 4/23 (17%) patients had a single TCR gene rearrangement in the Vɣ1-8 region. In contrast, the second group had 13/20 (65%) patients with a single TCR gene rearrangement in the Vɣ1-8 region (p=0.002). The presence of a single TCR gene rearrangeme...Continue Reading

References

Apr 1, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J van Dongen, I L Wolvers-Tettero
Apr 23, 2003·The Journal of Molecular Diagnostics : JMD·Lyle C LawnickiTimothy C Greiner
May 7, 2004·The New England Journal of Medicine·Michael GirardiLynn D Wilson
Apr 21, 2005·The Journal of Clinical Investigation·Ellen J KimAlain H Rook
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kei-ichi YamanakaThomas S Kupper
Jul 20, 2007·Archives of Dermatology·Vincent D Criscione, Martin A Weinstock
Jun 12, 2008·Journal of Cutaneous Pathology·Gregory A HoslerJ Margaret Moresi
Aug 2, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rakhshandra TalpurMadeleine Duvic
Dec 1, 2007·Expert Opinion on Medical Diagnostics·Anton W LangerakJacques Jm van Dongen
Jan 21, 2014·Journal of the American Academy of Dermatology·Sarah I JawedChristiane Querfeld
Mar 22, 2014·The Journal of Investigative Dermatology·Pooja Chitgopeker, Debjani Sahni
Jun 14, 2014·The Journal of Investigative Dermatology·Christian GünschmannLukas Scharfenberger
Mar 31, 2015·Clinical Lymphoma, Myeloma & Leukemia·Silvia Alberti-ViolettiMadeleine Duvic
Jun 7, 2015·Journal of the American Academy of Dermatology·Kari E SufficoolEric J Duncavage
Nov 27, 2015·American Journal of Hematology·Ryan A Wilcox

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