PMID: 4287060Mar 1, 1966

Specific transplantation immunity in relation to Rous sarcoma virus tumorigenesis in mice

The Journal of Experimental Medicine
N Jonsson, H O Sjögren


Tests for transplantation immunity and for the occurrence of virus-neutralizing serum antibodies were performed on mice, inoculated when newborn with the Schmidt-Ruppin strain of Rous sarcoma virus (RSV-SR). Mice developing no palpable primary sarcomas showed a clear-cut resistance against the isografting of established specifically antigenic Rous tumors. Transplantation tests performed on primary tumor hosts after extirpation of the tumors revealed neither any clear-cut immunity nor tolerance to the specific transplantation antigen(s). Serial pretreatment of operated primary tumor animals with irradiated autologous or syngeneic tumor cells resulted in a clear-cut transplantation immunity. Virus-neutralizing activity was only found in a few sera from newborn infected mice, and in these cases there was no positive correlation with the transplantation immunity. It seems probable that a successful immunization against the RSV-SR specific transplantation antigen(s) prevents the development of primary tumors. There is no indication of any tolerance to this antigen in connection with the induction of primary tumors.


Oct 1, 1965·Experimental Cell Research·N Jonsson, H O Sjögren
Jul 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·H RUBINL FANSHIER
Jan 1, 1962·The Journal of Experimental Medicine·K HABEL
Aug 1, 1965·The Journal of Experimental Medicine·N Jonsson, H O SJOEGREN


May 1, 1968·Acta Pathologica Japonica·T Ito
Jan 1, 1976·Transplantation Reviews·G Haughton, A C Whitmore
Dec 1, 1968·Japanese Journal of Medical Science & Biology·K YamanouchiF Kobune
Mar 1, 1983·European Journal of Cancer & Clinical Oncology·N KuzumakiT O Yoshida
Mar 15, 1973·International Journal of Cancer. Journal International Du Cancer·H Gelderblom, H Bauer

Related Concepts

Rous Sarcoma
Neoplasm Transplantation
Neoplasms, Experimental
Transplantation Immunology
Transplantation, Autologous
Transplantation, Homologous

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