Specific tricyclic antidepressant binding sites in rat brain characterised by high-affinity 3H-imipramine binding

European Journal of Pharmacology
R RaismanS Z Langer

Abstract

The specific binding of 3H-imipramine to various brain regions of the rat is of high affinity (Kd = 4.0 nM), rapid and reversible. It was inhibited by tricyclic antidepressants at nanomolar concentrations and by atypical antidepressants at micromolar concentrations. The binding does not seem to be directly related to known neurotransmitter receptor systems. Specific 3H-imipramine binding sites were unequally distributed between the various brain regions and undetectable in the heart and vas deferens. Rats chronically treated with desipramine for three weeks had significantly less specific 3H-imipramine binding sites in the cortex than did control animals. It is concluded that these 3H-imipramine binding sites may be important in the study of depression and of the mechanism of action of antidepressant drugs.

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Citations

Sep 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·S Z LangerP L Morselli
May 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·N D DanchevV A Zagorevskiĭ
Jan 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·A Ia KorneevT B Chan
Jan 1, 1985·Journal of Neural Transmission·H Rommelspacher, S Strauss
Aug 15, 1984·Experientia·A Davis
Apr 6, 1981·Brain Research·M PalkovitsS Z Langer
Jun 13, 1980·European Journal of Pharmacology·M S BrileyS Z Langer
May 30, 1980·European Journal of Pharmacology·S Z LangerM S Briley
Jul 10, 1981·European Journal of Pharmacology·M Briley, S Z Langer
May 21, 1982·European Journal of Pharmacology·H HallL Gawell
Apr 8, 1982·European Journal of Pharmacology·G M De MontisA Tagliamonte
Jan 21, 1983·European Journal of Pharmacology·A DavisS W Tang
Jun 3, 1983·European Journal of Pharmacology·L L Peterson, T Bartfai
Nov 11, 1983·European Journal of Pharmacology·C S Cascio, K J Kellar
Jul 20, 1984·European Journal of Pharmacology·P D Hrdina
Nov 26, 1985·European Journal of Pharmacology·E HabertS Z Langer
May 10, 1988·European Journal of Pharmacology·R KrulíkK Fuksová
Mar 1, 1983·Neuropharmacology·K FuxeP Eneroth

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