PMID: 3487380Jan 1, 1986Paper

Specific tumoricidal activity of cytotoxic macrophages and cytotoxic lymphocytes

Cancer Immunology, Immunotherapy : CII
H F DullensW Den Otter

Abstract

The antitumor potency and specificity of syngeneic immune peritoneal exudate cells were tested. Groups of DBA/2 mice were immunized against syngeneic SL2 tumor cells. Then 6 days after the last immunization the antitumor potency, and the specificity of the immunization reaction was tested by injecting groups of the immunized mice with 10(3) to 5 X 10(7) DBA/2 derived L1210, L5178Y, P815 or SL2 tumor cells, and injecting immune peritoneal exudate cells into DBA/2 mice which had been injected 2 h earlier i.p. with 2 X 10(4) or 2 X 10(5) L1210, L5178Y, P815, or SL2 cells. Furthermore the tumor specific cytotoxicity in vitro of isolated immune (vs SL2) peritoneal macrophages was tested against L1210, L5178Y, P815, and SL2 cells. The "reciprocal" experiments (previous immunization against L1210, L5178Y, or P815 cells and 'challenge' with SL2) were also done. Finally, we tested the tumor-specific cytotoxicity of isolated immune peritoneal T-lymphocytes. It was shown that the rejection of tumor cells in previously immunized mice, the antitumor efficacy of the transferred immune peritoneal exudate cells and the in vitro cytotoxicity of purified immune peritoneal macrophages and lymphocytes, were tumor-specific reactions. That is only b...Continue Reading

Related Concepts

Peritoneal Fluid (Body Substance)
Immunologic Tumoricidal Activities
Graft Rejection
Normal Serum Globulin Therapy
Macrophage
Mice, Inbred DBA
Neoplasm Transplantation
Neoplasms, Experimental
TC2 Cells

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