Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer

International Journal of Biological Sciences
Aolin LiZhiming Cai

Abstract

Fatty acid synthesis is regulated by transcription factors SREBPs and their escort protein SCAP. Malignant cells become dependent on de novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. Increasing evidence showed SCAP participated in various disease processes including malignant tumors, which regulate transcription factors SREBPs Tumorigenesis is associated with incur glucose consumption and lipogenesis. In our study, we discovered that SCAP was upregulated in BC tissues. SCAP knockdown by CRISPR-Cas9 inhibit the cell proliferation, invasion and migration. Additionally, the cell apoptosis was facilitated. What's more, downregulation of SCAP could weaken the cancer-promoting effects of estrogen on BC. Our study revealed that SCAP played a carcinogenic role in BC and lipogenesis might promote the initiation of BC by inducing SCAP. Thus, Targeting SCAP may provide a promising means of treating BC and a new perspective for the tumorigenesis of bladder cancer.

Citations

Sep 17, 2020·Cells·Niccolo' RodaMarco Giorgio
Apr 16, 2020·International Journal of Molecular Sciences·Virginia Sara Grancieri do AmaralEleonora Kurtenbach
Jun 7, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Maciej RomanWojciech M Kwiatek

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Methods Mentioned

BETA
PCR
gene knockout
gene knockdown

Software Mentioned

SPSS

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