PMID: 1184962Dec 1, 1975Paper

Specifically cytotoxic human and mouse lymphoid cells induced with antibody or antigen-antibody complexes.

The Journal of Immunology : Official Journal of the American Association of Immunologists
E SakselaO Mäkelä

Abstract

Human or mouse lymphoid cells could be "armed" with anti-NIP antibodies to become cytotoxic to NNP-conjugated fowl erythrocytes (NNP and NIP are closely related haptens). The arming factor was neutralized by a sufficient concentration of NIP-BSA (twice the concentration causing maximal precipitation) but low concentrations (e.g., 7% of the maximal precipitation concentration) increased the arming capacity.

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
T ImirO Mäkelä
The Journal of Immunology : Official Journal of the American Association of Immunologists
A V MuchmoreR M Blaese
The Journal of Immunology : Official Journal of the American Association of Immunologists
P GarredT E Mollnes
© 2022 Meta ULC. All rights reserved