Specification and morphogenesis of the zebrafish larval head skeleton

Developmental Biology
Charles B KimmelC B Moens

Abstract

Forward genetic analyses can reveal important developmental regulatory genes and how they function to pattern morphology. This is because a mutated gene can produce a novel, sometimes beautiful, phenotype that, like the normal phenotype, immediately seems worth understanding. Generally the loss-of-function mutant phenotype is simplified from the wild-type one, and often the nature of the pattern simplification allows one to deduce how the wild-type gene contributes to patterning the normal, more complex, morphology. This truism seems no less valid for the vertebrate head skeleton than for other and simpler cases of patterning in multicellular plants and animals. To show this, we review selected zebrafish craniofacial mutants. "Midline group" mutations, in genes functioning in one of at least three signal transduction pathways, lead to neurocranial pattern truncations that are primarily along the mediolateral axis. Mutation of lazarus/pbx4, encoding a hox gene partner, and mutation of valentino/kreisler, a hox gene regulator, produce anterior-posterior axis disruptions of pharyngeal cartilages. Dorsoventral axis patterning of the same cartilages is disrupted in sucker/endothelin-1 mutants. We infer that different signal transduc...Continue Reading

References

Feb 1, 1995·Trends in Neurosciences·S Guthrie
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·K HattaC B Kimmel
Nov 15, 1996·Science·A Lumsden, R Krumlauf
Apr 1, 1997·Developmental Biology·C P Heisenberg, C Nüsslein-Volhard
May 8, 1997·Nature·M ManzanaresR Krumlauf
Jun 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T F Schilling
Oct 10, 1997·Cell and Tissue Research·V RobinsonD G Wilkinson
May 16, 1998·Nature·F Casares, R S Mann
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·M R RebagliatiI B Dawid
Sep 18, 1998·Mechanisms of Development·P Francis-WestA Graveson
Nov 11, 1998·Developmental Biology·C B KimmelH C Snyder
Jul 9, 1999·Developmental Biology·M ManzanaresR Krumlauf
Oct 27, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D M NodenC P Emerson
Nov 24, 1999·Mechanisms of Development·E GaleM Maden
Mar 21, 2000·Genesis : the Journal of Genetics and Development·A L RubinsteinM E Halpern
Feb 10, 2000·Nature·A F Schier, M M Shen
Jun 20, 2000·Trends in Genetics : TIG·M KühlR T Moon
Jun 20, 2000·Trends in Genetics : TIG·M M Shen, A F Schier
Sep 21, 2000·Current Biology : CB·H I SirotkinW S Talbot
Aug 1, 1996·Journal of Morphology·Carol C Cubbage, Paula M Mabee

❮ Previous
Next ❯

Citations

May 16, 2003·Nature·J A Helms, R A Schneider
Feb 14, 2013·Nature Communications·Carlos Pardo-MartinMehmet Fatih Yanik
Aug 29, 2001·Journal of Anatomy·C B KimmelR J Keynes
Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jedd M HillegassLori A White
Apr 24, 2008·Development, Growth & Differentiation·Koji Fujimura, Norihiro Okada
Oct 18, 2011·Development, Growth & Differentiation·Andrea M J WeinerNora B Calcaterra
Sep 8, 2007·The Journal of Clinical Investigation·Yukio NakamuraMatthew L Warman
Mar 12, 2010·PloS One·Charles B KimmelMarcie McFadden
Jul 30, 2011·PloS One·Maria CattellDaniel Meulemans Medeiros
Feb 2, 2012·PloS One·Andrea M J WeinerNora B Calcaterra
Mar 7, 2014·BMC Evolutionary Biology·Masahito TsuboiNiclas Kolm
May 17, 2011·Gene Expression Patterns : GEP·Kentaro HiroseYutaka Kikuchi
Jul 30, 2009·Matrix Biology : Journal of the International Society for Matrix Biology·Dominique BaasFlorence Ruggiero
May 10, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Caroline ReynaudPascal Sommer
Nov 30, 2005·Journal of Anatomy·James Hanken, Joshua B Gross
Jun 12, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shannon C LuntBrian D Perkins
Nov 27, 2008·Journal of Morphology·Jeffrey M EngemanPaula M Mabee
Mar 5, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Christopher Rose
Jan 29, 2011·American Journal of Medical Genetics. Part a·Dwight R CorderoJill A Helms
Nov 23, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kelly Sheehan-RooneyMichael J Dixon
Apr 6, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Vida Senkus MelvinTrevor Williams
Jun 3, 2009·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Chisako NakadaSumiko Watanabe
Apr 10, 2016·Developmental Biology·Neil McCarthyJohann K Eberhart
Oct 3, 2006·Mechanisms of Development·Chris HallPhil Crosier
Apr 28, 2004·Mechanisms of Development·Hidenori OzekiHiroki Kurihara
Aug 6, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Amanda L Herberger, Christopher A Loretz
Jun 28, 2005·Developmental Biology·Ralph S MarcucioJill A Helms
Nov 16, 2010·Developmental Biology·Priya ChoudhryNikolaus Trede
Jul 25, 2006·Developmental Biology·Mariko SatoH Joseph Yost
May 11, 2005·Developmental Biology·Hung-Hsiang Yu, Cecilia B Moens
Jun 20, 2012·Developmental Biology·Mary E SwartzJohann K Eberhart
Nov 28, 2009·Developmental Biology·Heather L Szabo-RogersKaren J Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.