Specification and Patterning of Drosophila Appendages

Journal of Developmental Biology
Mireya Ruiz-LosadaCarlos Estella

Abstract

Appendages are external projections of the body that serve the animal for locomotion, feeding, or environment exploration. The appendages of the fruit fly Drosophilamelanogaster are derived from the imaginal discs, epithelial sac-like structures specified in the embryo that grow and pattern during larva development. In the last decades, genetic and developmental studies in the fruit fly have provided extensive knowledge regarding the mechanisms that direct the formation of the appendages. Importantly, many of the signaling pathways and patterning genes identified and characterized in Drosophila have similar functions during vertebrate appendage development. In this review, we will summarize the genetic and molecular mechanisms that lead to the specification of appendage primordia in the embryo and their posterior patterning during imaginal disc development. The identification of the regulatory logic underlying appendage specification in Drosophila suggests that the evolutionary origin of the insect wing is, in part, related to the development of ventral appendages.

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Citations

Aug 8, 2019·G3 : Genes - Genomes - Genetics·Michael D RotelliBrian R Calvi
Mar 8, 2020·Journal of Evolutionary Biology·Patrick T Rohner
Jan 21, 2021·Proceedings. Biological Sciences·Yonggang Hu, Armin P Moczek
Apr 20, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Susanne Thümecke, Reinhard Schröder
Jun 11, 2021·Nature·Ritsuko MoritaHironobu Fujiwara
Jun 11, 2021·Nature·Nivedita Saxena, Michael Rendl
Jul 20, 2021·PLoS Genetics·Kami Ahmad, Steven Henikoff
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Mireya Ruiz-LosadaCarlos Estella

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Methods Mentioned

BETA
dissection
X-ray
ChIP
Immunoprecipitation
imaging techniques

Software Mentioned

Antp

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