PMID: 9535512Apr 16, 1998Paper

Specification of left-right asymmetry in mammals: embryo culture studies of stage of determination and relationships with morphogenesis and growth

Reproductive Toxicology
A McCarthy, N A Brown

Abstract

The internal mammalian body plan is laterally asymmetric with a consistent handedness such that some organs are placed on one side (stomach on the left, for example) and paired organs are not symmetric (for example, there are more lung lobes on the right). Some chemical teratogens can affect the development of asymmetry, and some can cause asymmetric defects in overtly symmetric structures, but the mechanisms are unknown. We have used chemical treatment of rat embryos in culture to examine the stage at which the left-right axis is determined and show that all effective treatments can affect left-right axis development up to the early headfold stage, but not from late headfold onwards. This suggests that the left-right axis is determined by the late headfold stage, even though the embryo is overtly symmetric at this stage. It appears to be much easier to induce an abnormal left-right axis from late allantoic bud and early headfold stages than the early allantoic bud stage, but we have not established the earliest stage at which a response can be induced. Complete situs inversus was the most common chemically induced abnormality, although heart looping and body turning could be inverted separately, suggesting that the two phenome...Continue Reading

References

Jan 1, 1991·Developmental Biology·M Fujinaga, J M Baden
Nov 1, 1994·Trends in Genetics : TIG·A J Klar
Apr 1, 1997·Current Biology : CB·T King, N A Brown
Mar 1, 1969·Wilhelm Roux' Archiv Für Entwicklungsmechanik Der Organismen·Alfred Wehrmaker

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Citations

Jan 28, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R Shane TubbsW Jerry Oakes
Apr 5, 2011·International Journal of Pediatric Otorhinolaryngology·Lei LiuHaiyue Jiang
Nov 3, 2006·Journal of Advanced Nursing·Shannon Scott-Findlay, Carole A Estabrooks
Aug 19, 2006·International Journal of Mental Health Nursing·Andrea McCloughen, Louise O'Brien
Apr 8, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Giovanni Marzullo, Charles E Boklage
Aug 31, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert G Ellis-Hutchings, Edward W Carney
Mar 2, 1999·Developmental Biology·Q TangD Goldowitz
Mar 4, 2000·Toxicology and Applied Pharmacology·A M Saillenfait, J P Sabaté
Jun 13, 2014·Journal of Transcultural Nursing : Official Journal of the Transcultural Nursing Society·Ji-Young AnHaeran Jang
Jul 2, 2010·Journal of Transcultural Nursing : Official Journal of the Transcultural Nursing Society·Ji-Young AnJeanne S Ruggiero
Jun 26, 2015·British Journal of Nursing : BJN·Ann MulsAnna-Marie Stevens
Dec 3, 2003·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R Shane TubbsW Jerry Oakes
Nov 24, 2018·Development·Audrey DesgrangeSigolène M Meilhac

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