Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish

Current Biology : CB
Benjamin M HoganGraham J Lieschke

Abstract

In the zebrafish embryo, primitive hematopoiesis initiates in two spatially distinct regions. Rostrally, the cells of the anterior lateral plate mesoderm (ALPM) give rise exclusively to cells of the myeloid lineage in a pu.1-dependent manner. Caudally, in the posterior lateral plate mesoderm (PLPM), the expression of gata1 defines a precursor pool that gives rise predominantly to the embryonic erythrocytes. The transcription factor scl acts upstream of both gata1 and pu.1 in these precursor pools, activating a series of conserved transcription factors that cell-autonomously specify either myeloid or erythroid fates. However, the mechanisms underlying the spatial separation of the hematopoietic precursor pools and the induction of differential gene expression within these pools are not well understood. We show here that the Bmp receptor lost-a-fin/alk8 is required for rostral pu.1 expression and myelopoiesis, identifying an early genetic event that distinguishes between the induction of anterior and posterior hematopoiesis. Introducing a constitutively active version of the Alk8 receptor led to increased pu.1 expression, but the role of alk8 was independent of the scl-dependent cell-fate pathway. Furthermore, the role of Alk8 in...Continue Reading

References

May 5, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P C YelickP Stashenko
Jul 22, 1998·The EMBO Journal·M GeringA R Green
Sep 10, 1999·Developmental Biology·Y MishinaR R Behringer
Jul 13, 2001·Current Opinion in Genetics & Development·A F Schier
Jul 27, 2001·Blood·C M BennettA T Look
Dec 19, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C E WillettL A Steiner
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Susan E LyonsP Paul Liu
Dec 4, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T L Payne-Ferreira, P C Yelick
Mar 24, 2004·Mechanisms of Development·Marek DudasVesa Kaartinen
Jul 1, 2004·Development·Vesa KaartinenJonathan A Epstein
Dec 29, 2004·Developmental Cell·Jennifer RhodesJohn P Kanki
Dec 29, 2004·Developmental Cell·Jenna L GallowayLeonard I Zon
Jan 20, 2005·The Journal of Experimental Medicine·Stephen L NuttLi Wu

❮ Previous
Next ❯

Citations

Sep 1, 2007·Blood·Lisa J McReynoldsTodd Evans
Jan 10, 2008·Blood·Duncan Carradice, Graham J Lieschke
Sep 18, 2009·Blood·Devorah C GoldmanWilliam H Fleming
Jan 10, 2012·Disease Models & Mechanisms·Stephen A Renshaw, Nikolaus S Trede
Sep 9, 2011·PloS One·Maria-Cristina KeightleyGraham J Lieschke
Jan 23, 2014·The International Journal of Biochemistry & Cell Biology·Zhenhong SuQing K Wang
Jul 25, 2014·The International Journal of Biochemistry & Cell Biology·Maria-Cristina KeightleyGraham J Lieschke
Oct 2, 2012·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jin XuZilong Wen
Dec 10, 2008·Developmental and Comparative Immunology·Patrick C HaningtonMiodrag Belosevic
May 6, 2009·Journal of Cellular Biochemistry·Stuart T Fraser, Margaret H Baron
Jul 22, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hendrik MommaertsPrzemko Tylzanowski
Mar 29, 2008·Cell Stem Cell·Claudia LengerkeGeorge Q Daley
Mar 31, 2007·Developmental Biology·Sonja ChocronJeroen Bakkers
Apr 7, 2017·Nature Communications·Maria-Cristina KeightleyGraham J Lieschke
Jan 8, 2011·Circulation Research·Michela NosedaMichael D Schneider
Nov 22, 2018·Cell Death and Differentiation·Chun-Xiao HuangHuan-Ling Wang
Jun 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Arif KirmizitasRoger Patient
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Kelly Z MiaoHui Feng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.