PMID: 8943903Dec 1, 1996Paper

Specificities of anti-platelet antibodies in multitransfused patients with haemato-oncological disorders

British Journal of Haematology
M KurzS Panzer

Abstract

The clinical condition and the formation of platelet-reactive antibodies influence the post-transfusion platelet increment. We analysed the specificities of platelet-reactive antibodies in 81 multitransfused patients with haemato-oncological diseases refractory to platelet transfusions, or prior to a scheduled stem cell transplantation. In 17 additional patients we prospectively determined the development of platelet-reactive antibodies at the time of chemotherapy in weekly intervals. Sera were tested by the monoclonal antibody-specific immobilization of platelet antigens (MAIPA)-technique for antiplatelet antibodies against HLA class I antigens, the human platelet-specific alloantigens (HPA)-1, -2, -3, -5, and the platelet membrane glycoproteins (GP) Ia/IIa, Ib/IX, IIb/IIIa (panreactive). Platelet reactive antibodies were found in 54% of blood samples. They were frequent in patients with a history of possible previous immunization, particularly if patients were refractory to platelet transfusions. Platelet-reactive HLA antibodies were the most common antibodies. Even patients without a known risk of primary immunization who received exclusively leucocyte-depleted blood products formed antibodies. By the MAIPA technique, even L...Continue Reading

Citations

Sep 6, 2000·British Journal of Haematology·L M Williamson
Jun 16, 2001·Transfusion·V KiefelS Santoso
Apr 19, 2002·Transfusion·Satoshi SaitoHiroo Maeda
Sep 28, 2007·Current Opinion in Hematology·Ralph R Vassallo
Aug 18, 2005·European Journal of Haematology·Hadef SkouriPhilippe Bierling
Apr 25, 2007·Acta Clinica Belgica·A BoslyD Sondag
Jul 22, 2015·British Journal of Haematology·Simon J StanworthJudith Marsh
May 27, 2006·Human Immunology·Anneke BrandBert Tomson
Jan 27, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hacene BroukHanifa Ouelaa
Apr 10, 2003·Archives of Pathology & Laboratory Medicine·Ronald A SacherUNKNOWN College of American Pathologists.Transfusion Medicine Resource Committee

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