PMID: 7524536DOI: 10.1016/0952-7915(94)90140-6Aug 1, 1994Paper
Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes
Current Opinion in Immunology
L K Selin, R M Welsh
Abstract
Recent studies have defined an immunological network by which the acute cytotoxic T-lymphocyte response to viral infection modulates or is modulated by the antigen load and by crossreactive memory T cells. Down regulation of the acute CTL response can be associated with either antigen-dependent or antigen-independent apoptosis, and the host enters a state of immune deficiency as these T cells become sensitized to apoptotic mechanisms.
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