PMID: 9046Jan 1, 1976

Specificity and inhibition of gamma-glutamyl transpeptidase in guinea pig intestines

Archivum Immunologiae Et Therapiae Experimentalis
K A Sobiech, A Szewczuk


Gamma-Glutamyl transpeptidase activity in guinea pig intestine was tested toward 8 monoglutamyl and 4 diglutamyl substrates. Distinct differences in specificity and activity related to ontogenetic development were noted. A mixture of L-serine and borate inhibited specifically gamma-glutamyl transpeptidase activity of homogenates and accumulation of naphthylamine and 14C-substances in slices of intestine incubated with gamma-L-14C-glutamyl-alpha-naphthylamide. The same mixture, administered per os together with 14C-gamma-glutamyl substrate, specifically inhibited urinary excretion of 14C-substance, but had no effect on the rate of excretion of glycine, L-glutamic acid or L-pyroglutamic acid.

Related Concepts

Gamma-glutamyl transferase
Cavia porcellus
Structure of Intestinal Gland

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