Specificity in Ubiquitination Triggered by Virus Infection.

International Journal of Molecular Sciences
Haidong Gu, Behdokht Jan Fada

Abstract

Ubiquitination is a prominent posttranslational modification, in which the ubiquitin moiety is covalently attached to a target protein to influence protein stability, interaction partner and biological function. All seven lysine residues of ubiquitin, along with the N-terminal methionine, can each serve as a substrate for further ubiquitination, which effectuates a diverse combination of mono- or poly-ubiquitinated proteins with linear or branched ubiquitin chains. The intricately composed ubiquitin codes are then recognized by a large variety of ubiquitin binding domain (UBD)-containing proteins to participate in the regulation of various pathways to modulate the cell behavior. Viruses, as obligate parasites, involve many aspects of the cell pathways to overcome host defenses and subjugate cellular machineries. In the virus-host interactions, both the virus and the host tap into the rich source of versatile ubiquitination code in order to compete, combat, and co-evolve. Here, we review the recent literature to discuss the role of ubiquitin system as the infection progresses in virus life cycle and the importance of ubiquitin specificity in the regulation of virus-host relation.

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·I L Goldknopf, H Busch
Jan 24, 1977·Biochemical and Biophysical Research Communications·L T Hunt, M O Dayhoff
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Jan 5, 2000·The EMBO Journal·J S ThrowerC M Pickart
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·B StrackH G Gottlinger
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·R N HartyF P Hayes
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KikonyogoJ Leis
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACSR C VALENTINE
Feb 1, 2005·Journal of Virology·Christopher M WiethoffGlen R Nemerow
Apr 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yu LiangBernard Roizman
Sep 29, 2006·The EMBO Journal·Takayoshi KirisakoKazuhiro Iwai
Jan 26, 2007·Journal of Virology·Joanne ElliottJames A Johnston
Jan 13, 2009·Nature Cell Biology·Fuminori TokunagaKazuhiro Iwai
Apr 9, 2009·Nature Reviews. Molecular Cell Biology·Brenda A Schulman, J Wade Harper
Oct 28, 2009·The Journal of Biological Chemistry·Andrew D JacobsonChang-Wei Liu
Mar 25, 2010·PLoS Pathogens·Harald WodrichEric J Kremer
Jun 12, 2010·Immunological Reviews·Gordon J FreemanRosemarie H DeKruyff
Apr 23, 2011·Nature·Thomas PertelJeremy Luban
Sep 13, 2011·Molecular Cell·Woong KimSteven P Gygi
Apr 10, 2012·Annual Review of Biochemistry·Koraljka Husnjak, Ivan Dikic
Apr 25, 2012·Annual Review of Biochemistry·David Komander, Michael Rape

❮ Previous
Next ❯

Citations

Jan 7, 2021·Cellular & Molecular Biology Letters·Michal Tracz, Wojciech Bialek

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
deubiquitination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Kazuhiro Iwai
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yane-Shih WangRuey-Hwa Chen
© 2022 Meta ULC. All rights reserved