PMID: 11934497Apr 6, 2002Paper

Specificity of a heme-assimilating system of Vibrio vulnificus to synthetic heme compounds

FEMS Microbiology Letters
Shin-ichi MiyoshiShigeo Yamamoto

Abstract

Vibrio vulnificus strain L-180, a clinical isolate, can obtain iron from a synthetic heme, iron-tetra(4-sulfonatophenyl)porphyrin (Fe-TPPS), as well as from a natural heme, protoheme. This assimilation of iron bound to TPPS was demonstrated to be a common property of V. vulnificus by testing a total of 27 strains isolated from both clinical and environmental sources. Strain L-180 could also utilize Fe-TCPP, but not Fe-TMPyP, as a sole iron source. TPPS or its complex with a metal ion reduced bacterial multiplication in the broth containing a minimum dose of Fe-TPPS. When inoculated into human serum supplemented with Fe-TCPP, L-180 could grow only in the presence of a protease from the same bacterium. In both TPPS and TCPP, each side chain of a porphyrin ring has a negative charge. Therefore, this negative charge may be important for interaction with an outer membrane receptor involving in a heme-assimilating system of V. vulnificus.

References

Jan 1, 1992·Critical Reviews in Microbiology·B R OttoD M MacLaren
Aug 19, 1991·Ugeskrift for laeger·H K Andersen
Apr 1, 1984·The Journal of Infectious Diseases·C O TacketP A Blake
Nov 1, 1981·Infection and Immunity·A C WrightJ D Oliver
May 1, 1994·The International Journal of Biochemistry·J BartosováZ Hrkal
Mar 1, 1997·FEMS Microbiology Letters·S MiyoshiS Shinoda
Dec 11, 1997·Journal of Bacteriology·S MiyoshiS Shinoda
May 19, 2000·Infection and Immunity·C P Shao, L I Hor
Jul 15, 2000·The Journal of Biological Chemistry·M H SorgineP L Oliveira

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Citations

Jul 6, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Sumio Shinoda

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