Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Aaron NagielA J Hudspeth

Abstract

The proper wiring of the vertebrate brain represents an extraordinary developmental challenge, requiring billions of neurons to select their appropriate synaptic targets. In view of this complexity, simple vertebrate systems provide necessary models for understanding how synaptic specificity arises. The posterior lateral-line organ of larval zebrafish consists of polarized hair cells organized in discrete clusters known as neuromasts. Here we show that each afferent neuron of the posterior lateral line establishes specific contacts with hair cells of the same hair-bundle polarity. We quantify this specificity by modeling the neuron as a biased selector of hair-cell polarity and find evidence for bias from as early as 2.5 d after fertilization. More than half of the neurons form contacts on multiple neuromasts, but the innervated organs are spatially consecutive and the polarity preference is consistent. Using a novel reagent for correlative electron microscopy, HRP-mCherry, we show that these contacts are indeed afferent synapses bearing vesicle-loaded synaptic ribbons. Moreover, afferent neurons reassume their biased innervation pattern after hair-cell ablation and regeneration. By documenting specificity in the pattern of neu...Continue Reading

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Citations

Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Aaron NagielA J Hudspeth
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hironori WadaAlain Ghysen
May 25, 2012·PloS One·Michael StobbEthan Gahtan
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zev EinhornTeresa Nicolson
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Josef G Trapani, Teresa Nicolson
Oct 19, 2014·Neural Development·Maria Laura CeciMiguel L Allende
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michelle R GleasonA J Hudspeth
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Sep 28, 2018·Frontiers in Cell and Developmental Biology·Katie S Kindt, Lavinia Sheets
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