PMID: 51832Jul 15, 1975Paper

Specificity of cell-mediated cytotoxicity against human melanoma lines: evidence for "non-specific" killing by activated T-cells

International Journal of Cancer. Journal International Du Cancer
P HerseyD S Nelson

Abstract

The specificity of cell-mediated cytotoxicity against melanoma cells in vitro has been analyzed in a large number of studies with cells both from normal and melanoma subjects. As in a number of other, recent, similar human studies, no evidence for tumour specificity was found. Effector cells in peripheral blood responsible for the cytotoxic raction were examined by cell separation methods based on red cell rosette formation and separation through Hypaque-Ficoll mixtures. The evidence suggests that non-specificity results from killing by cells separating largely in the non-sheep red blood cell rosetting fraction and which have cytotoxic specificity directed broadly to cells with abnormal membranes. Further analysis revealed that the cells were non-phagocytic and did not bear receptors for complement. They appear to be activated into cell division and to bear surface receptors for the Fc portion of IgG. Additional evidence is presented suggesting that the cells mainly responsible are activated thymus-dependent cells present in the circulation of both tumour-bearing and normal subjects.

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Citations

Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M G MasucciW Berthold
Jul 1, 1984·The Journal of Experimental Medicine·H YsselJ E de Vries
Feb 1, 1978·The Australian and New Zealand Journal of Surgery·A E Bray
Oct 1, 1977·Australian and New Zealand Journal of Medicine·P Hersey
Aug 1, 1979·Australian and New Zealand Journal of Medicine·P Hersey
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·T E Carey
Sep 15, 1979·International Journal of Cancer. Journal International Du Cancer·S H GolubJ V Zielske
Jun 15, 1977·International Journal of Cancer. Journal International Du Cancer·D Akira, M Takasugi
May 15, 1978·International Journal of Cancer. Journal International Du Cancer·E MurrayP Hersey
May 15, 1978·International Journal of Cancer. Journal International Du Cancer·R L VessellaM E Kaplan
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·T BakácsE Klein
Nov 15, 1978·International Journal of Cancer. Journal International Du Cancer·Y KoideM Takasugi
Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·O EreminJ Ashby
Aug 1, 1986·Cellular Immunology·N GengozianR A Good
Sep 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N ThatcherD Crowther
Jun 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P HerseyG W Milton
Feb 15, 1980·International Journal of Cancer. Journal International Du Cancer·P HerseyW H McCarthy
Dec 1, 1981·International Journal of Cancer. Journal International Du Cancer·P HerseyW H McCarthy
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May 1, 1982·Cellular Immunology·G MasucciE Klein
Sep 15, 1978·Cellular Immunology·M A Kall, H S Koren
Nov 1, 1977·European Journal of Immunology·B M VoseE Klein

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