Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction.

The American Journal of Cardiology
R RobertsB E Sobel

Abstract

Creatine phosphokinase (CPK) isoenzyme determinations are useful in the diagnosis of myocardial infarction. However, until suitably sensitive and precise quantitative procedures became available, the diagnostic specificity of serum CPK isoenzyme elevations could not be thoroughly examined. In this study an assay procedure capable of accurately determining activity of individual CPK isoenzymes even in serum samples with normal total CPK activity was employed to obtain two types of information. First, CPK isoenzyme profiles were examined in extracts of a spectrum of human tissues obtained at operation to determine whether the isoenzyme associated with myocardium is presented in other human tissues in quantities sufficient to produce increased activity in serum. In addition, CPK isoenzymes were analyzed quantitatively in serial serum samples from 50 hospitalized control subjects, 100 patients with acute myocardial infarction, 100 patients undergoing non-cardiac surgery and 50 patients undergoing cardiac catheterization to determine whether insult to tissues other than the heart is associated with increased "myocardial" CPK isoenzyme activity in serum. Results from analyses of tissue extracts indicated that myocardium is the only t...Continue Reading

References

Jul 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·A F Smith
Nov 1, 1973·Annals of Internal Medicine·R Roberts, B E Sobel
May 6, 1974·The American Journal of Cardiology·R RobertsB E Sobel
Jan 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Madsen
Jun 1, 1972·The American Journal of Cardiology·A Konttinen, H Somer
Jan 1, 1970·The American Journal of the Medical Sciences·H Y MeltzerM Boyer
Jul 1, 1970·The Journal of Pediatrics·R R WolfeA J Moss
Mar 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·K J van der Veen, A F Willebrands
Jan 1, 1955·The Journal of Clinical Investigation·A KARMENJ S LADUE
Dec 1, 1964·Annals of Internal Medicine·J W HESSD GROSS

❮ Previous
Next ❯

Citations

Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M P WhyteJ H Ladenson
Dec 29, 1977·Molecular and Cellular Biochemistry·A A Painter, R Roberts
Jan 15, 1985·Experientia·H Haibach, M W Hosler
Feb 1, 1981·Irish Journal of Medical Science·M HarteJ H Horgan
Nov 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R D SeegobinN Conway
Jan 1, 1984·Canadian Anaesthetists' Society Journal·H Rosenberg, G A Gronert
Feb 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·R RobertsC W Parker
Jul 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Lundin, I Styrélius
Sep 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·S A DannerA J Dunning
Oct 9, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·F L Wang, D W Cushman
Jun 18, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·V J WillsonR J Thompson
May 1, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Briem, L Rombo
Aug 4, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Grace, R Roberts
May 6, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·P R Desjardins
Jan 5, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·J MillerR Wei
Apr 1, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J A GimpelA H Maas
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·S SoferM Gueron
Aug 1, 1992·Journal of the American College of Cardiology·N A PragerD R Abendschein
May 1, 1994·Journal of the American College of Cardiology·S AbeK Kiyonaga
May 1, 1996·Journal of Clinical Anesthesia·P M BokeschR Grimaldi
Jul 1, 1991·Trends in Cardiovascular Medicine·R J HamburgM B Perryman
Aug 1, 1979·JACEP·M Reynolds, J W Jones
Jan 25, 2000·The Journal of Emergency Medicine·R Oosterbaan, M J Burns
May 5, 1977·The New England Journal of Medicine·L D Hillis, E Braunwald
Aug 25, 1977·The New England Journal of Medicine
Jan 19, 1978·The New England Journal of Medicine·R M NelsonI H Gessner
Oct 24, 1985·The New England Journal of Medicine·J S IngwallP D Allen
Nov 21, 1985·The New England Journal of Medicine·J E MullerT Robertson
Jan 6, 1994·The New England Journal of Medicine·R M Smith, T S Neuman
Jul 31, 2002·Heart Disease·Nagaraju L ChoragudiRichard Lucariello
Nov 25, 2003·Southern Medical Journal·Ali R RahimiChristian M Richard
Feb 1, 1992·Clinical and Experimental Pharmacology & Physiology·L L LeongR R Taylor
Nov 27, 1982·British Medical Journal·E M OhmanJ H Horgan
Jul 1, 1979·The Journal of Clinical Investigation·G L ConradK I Shine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.