PMID: 6167653Aug 1, 1981Paper

Specificity of fc receptors for IgG2a, IgG1/IgG2b, and IgE on rat macrophages

The Journal of Experimental Medicine
G Boltz-NitulescuH L Spiegelberg

Abstract

To characterize the Fc receptors on rat alveolar and peritoneal macrophages (M phi), we analyzed their ability to form rosettes with fixed ox erythrocytes (Eo') coated with myeloma proteins of all rat Ig classes and with fresh erythrocytes (Eo) sensitized with rat IgG1 and IgG2, rabbit IgG and IgM, and mouse IgA antibodies. The M phi formed rosettes with Eo' coated with rat myeloma proteins of classes IgG1, IgG2a, IgG2b, and IgE but not IgG2c, IgA, IgM, and IgD. Rat M phi also formed rosettes with Eo' coated with human IgG1, IgG3, IgG4, mouse IgG1, IgG2a, IgG2b, and rabbit IgG. Furthermore, rat M phi formed rosettes with Eo sensitized with rat IgG1, IgG2, or rabbit IgG antibodies but not with Eo sensitized with rabbit IgM or mouse IgA antibodies. Trypsin treatment of rat M phi abolished IgG1/IgG2b and IgE but not IgG2a rosettes. The IgG2a and IgE rosettes were Ig class specific because they were inhibited only by rat IgG2a and rat IgE, respectively. In contrast, IgG1 and IgG2b rosettes were inhibited equally by IgG1 and IgG2b. Heterologous IgG inhibited IgG1/IgG2b but not IgG2a rosettes. Rat IgE inhibited rat IgG1, IgG2b, and heterologous IgG rosette formation on rat M phi. Although Eo' coated with rat IgE formed rosettes with ...Continue Reading

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Citations

Sep 1, 1992·Cell and Tissue Research·A SchedleG Boltz-Nitulescu
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·G BoltzA Gangl
Aug 1, 1984·Agents and Actions·D M Weir
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Jan 1, 1991·Clinical Immunology and Immunopathology·C K Abrass

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