Specificity of initial synaptic contacts made on guinea-pig superior cervical ganglion cells during regeneration of the cervical sympathetic trunk

The Journal of Physiology
A Njå, D Purves

Abstract

1. Largely appropriate synaptic connexions are formed with neurones in the superior cervical ganglion at long intervals after interruption of the preganglionic nerve. In the present study we have assessed the accuracy of connexions during the early stages of re-innervation by observing end-organ responses to ventral root stimulation in vivo, and by recording intracellularly from ganglion cells during ventral root stimulation in isolated preparations. 2. Appropriate, but weak, end-organ responses were elicited by stimulation of the first and fourth thoracic ventral roots (T1 and T4) 15--30 days after freezing the cervical sympathetic trunk. 3. Intracellular recordings from ganglion cells during stimulation of the ventral roots C8--T7 in vitro showed that synaptic contacts are first re-established 8--11 days after freezing the preganglionic nerve. The proportion of re-innervated cells, and the strength of innervation of individual neurones, increased rapidly for up to about 3 months after nerve injury, but showed little change thereafter. Innervation remained weaker than normal even after 6 months. 4. Patterns of segmental innervation recorded intracellularly during the early stages of regeneration were similar to, but more restr...Continue Reading

Citations

Dec 1, 1992·Pharmacology & Therapeutics·I A Hendry
Aug 22, 1992·The Journal of Comparative Neurology·V Boss, D J Wigston
May 26, 1997·The Journal of Comparative Neurology·E B CornbrooksC J Forehand
Dec 1, 1983·The Journal of Comparative Neurology·B TaylorS D Roper
Mar 1, 1993·Journal of Neurobiology·K LiestølA Njå

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