PMID: 6972120Apr 4, 1981Paper

Specificity of the BT-PABA test for the diagnosis of exocrine pancreatic insufficiency in the dog

The Veterinary Record
R M Batt, L C Mann

Abstract

Exocrine pancreatic insufficiency in the dog has been assessed by the oral administration of the synthetic peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BT-PABA), a specific substrate for pancreatic chymotrypsin. The subsequent assay of PABA in either the plasma or the urine clearly differentiated control animals from those with exocrine pancreatic insufficiency (EPI), the results being unaffected by combination of this pancreatic function with a xylose absorption test. Possible interference with the specificity of the peptide test for the diagnosis of EPI was examined in six animals with small intestinal disease. In a group of four animals, with features resembling chronic tropical sprue in man, the results were comparable to those of the control group. In the fifth case, however, the results were indistinguishable from those of the EPI group, the estimation of sodium PABA absorption and the assay of proteolytic activity in the duodenal juice demonstrating that this was due to defective hydrolysis of the peptide. In the sixth case, diffuse intestinal lymphosarcoma and a marked villous atrophy were associated with an apparent reduction in the absorption of sodium PABA. However, although the plasma PABA concentrations followi...Continue Reading

Citations

Jun 8, 2002·Veterinary Immunology and Immunopathology·Takaki WaritaniTakatsugu Yamada
Oct 1, 1991·Alcoholism, Clinical and Experimental Research·D R WhitmireA R Dillon
Jul 1, 1991·Journal of Comparative Pathology·S LloydE J Soulsby
Sep 1, 1989·The Veterinary Clinics of North America. Small Animal Practice·R M JacobsV E Valli
Feb 13, 2004·The Journal of Veterinary Medical Science·Giuseppe PiccioneGiovanni Caola
Apr 1, 1989·Australian Veterinary Journal·A NicholsonJ R Mercer

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