Specificity of the comparative skin test for bovine tuberculosis in Great Britain

The Veterinary Record
Anthony V GoodchildRicardo de la Rua-Domenech

Abstract

A novel method for estimating specificity of the Single Intradermal Comparative Cervical Tuberculin (SICCT) test for bovine tuberculosis (bTB) using surveillance tests results is reported. The specificity of the SICCT test at three cut-offs was estimated from the dates, locations and skinfold measurements of all routine tests carried out in Officially TB Free (OTF) cattle herds in Great Britain (GB) between 2002 and 2008, according to their separation (by distance and time) from known infected (OTF-withdrawn) herds. The proportion of animals that tested positive was constant (P>0.20) when the distance between tested herds and nearest infected herd exceeded 8 km. For standard cut-off, calculated specificity was 99.98 per cent (95 per cent confidence interval ±0.004 per cent), equating to one false positive result per 5000 uninfected animals tested. For severe cut-off it was 99.91 per cent (±0.013 per cent) and for ultrasevere cut-off (selecting all reactors and inconclusive reactors) it was 99.87 per cent (±0.017 per cent). The estimated positive predictive value of the test averaged 91 per cent and varied by regional prevalence. This study provides further evidence of the high specificity of the SICCT test under GB conditions, ...Continue Reading

References

Nov 1, 1990·Australian Veterinary Journal·L CornerJ S Rothel
May 1, 1994·Veterinary Microbiology·M L MonaghanP J Quinn
Apr 20, 1999·Biologicals : Journal of the International Association of Biological Standardization·S TameniF Ciuchini
Mar 20, 2010·Preventive Veterinary Medicine·Dianna M WolfeS Wayne Martin
Oct 25, 2012·PLoS Computational Biology·Andrew J K ConlanJames L N Wood
Jun 12, 2013·Preventive Veterinary Medicine·M J GallagherS J More
Nov 14, 2013·Nursing Standard·Linda Nicholson

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Citations

May 27, 2016·BMC Veterinary Research·Michael K GhebremariamA L Michel
Jan 20, 2017·The Veterinary Record·F BuschS Rhodes
Feb 19, 2017·The Veterinary Record·K A HarrisP A Upton
Dec 24, 2017·Tropical Animal Health and Production·Victor O AkinseyeSimeon I B Cadmus
Mar 25, 2019·The Veterinary Record·L D PerrinP A Upton
Nov 30, 2019·The Veterinary Record·Christine MiddlemissZara Gerrard
Mar 30, 2020·The Veterinary Record·D DuncanP A Upton
Nov 30, 2019·Scientific Reports·Aneesh ChandranJohnjoe McFadden
Nov 26, 2016·Genetics, Selection, Evolution : GSE·Smaragda TsairidouJohn A Woolliams
May 13, 2018·The Veterinary Record·K A HarrisJ Dale
Dec 26, 2018·Frontiers in Veterinary Science·Smaragda TsairidouAndrea B Doeschl-Wilson
Dec 13, 2016·Journal of Dairy Science·G BanosM P Coffey
Apr 25, 2018·Frontiers in Veterinary Science·Margaret GoodDaniel M Collins
Aug 26, 2020·Animals : an Open Access Journal From MDPI·Jessica M AbbateGiovanni Lanteri
Jun 8, 2018·Frontiers in Veterinary Science·Tracy A CleggSimon J More
Oct 17, 2018·Frontiers in Veterinary Science·Lucy A BruntonSara H Downs
Jul 24, 2021·The Veterinary Record·E RimdapJ Dale
Oct 31, 2021·Transboundary and Emerging Diseases·Jesús Ruiz-CabelloJose L Izquierdo-García

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