Specificity of the isolectins from the plant cactus Machaerocereus eruca for oligosaccharides from porcine stomach mucin

Glycoconjugate Journal
E ZentenoH Debray

Abstract

Sugar specificity of the Machaerocereus eruca isolectins, MeAI and MeAII, has been determined by comparing the capacity of glycans with well defined structures to inhibit their haemagglutinating activity. Both are galactose-specific isolectins with high affinity for O-glycans. However, the two M. eruca isolectins recognize different oligosaccharidic sequences belonging to O-glycosidically linked glycans from porcine stomach mucin. The minimal structure recognized by MeAI on the porcine mucin glycans is the O-glycan core Gal beta 1,3GalNAc-ol, whereas MeAII has a more extended site and interacts with a biantennary O-glycan possessing the terminal trisaccharide Fuc alpha 1,2 (GalNAc alpha 1,3) Gal beta 1,4.

Citations

Dec 4, 2001·Biochimica Et Biophysica Acta·M Martínez-CruzF Córdoba
Jul 28, 2005·Protein Science : a Publication of the Protein Society·Celso S NaganoJuan J Calvete
Jun 12, 2003·Journal of Agricultural and Food Chemistry·Margarito Martínez-CruzFélix Córdoba
Jun 15, 2007·Journal of Agricultural and Food Chemistry·Adriana Castillo-VillanuevaEdgar Zenteno

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