PMID: 1211956Nov 1, 1975Paper

Specificity of ultrastructural changes of small intestinal epithelium in early childhood

Archives of Disease in Childhood
M Araya, J A Walker-Smith

Abstract

Electron microscopical features of the small intestinal mucosa in 30 consecutive biopsies from 14 newly diagnosed coeliac patients, and 16 patients with chronic intermittent diarrhoea due to different causes, were studied. An attempt to define specific changes in each condition was made. An abnormal brush border, increased number of free ribosomes, rich rough endoplasmic reticulum, poorly developed smooth endoplasmic reticulum, large Golgi complexes, and thickened basal lamina were the most frequent findings in the coeliac biopsies. These changes suggest abnormal cellular metabolism, but as they were also observed in children with a variety of clinical conditions, they could not be specifically related to coeliac disease. These observations suggest that in small children different causes leading to different degrees of abnormal small intestinal mucosa, as observed with the light microscope, produce nonspecific changes of the cellular ultrastructure, which cannot be related to the degree of abnormality observed at the light microscope level.

References

Oct 1, 1972·The Journal of Pediatrics·M E Ament
Jul 25, 1958·The Journal of Biophysical and Biochemical Cytology·M L WATSON
Jan 25, 1959·The Journal of Biophysical and Biochemical Cytology·R E HARTMANJ M MOLESWORTH
May 25, 1959·The Journal of Biophysical and Biochemical Cytology·S L PALAY, L J KARLIN
Mar 1, 1962·The Journal of Cell Biology·A L BROWN
Aug 1, 1961·Journal of Ultrastructure Research·B F TRUMPE P BENDITT

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Citations

Jun 26, 2002·Journal of Pediatric Gastroenterology and Nutrition·Paolo Lionetti
Jun 17, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M KorhonenE Savilahti
Sep 23, 2011·Scandinavian Journal of Gastroenterology·Richard L MonesGeraldine Mercer

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